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Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   OCTOBER 2014 , Volume 17 , Number 10; Page(s) 702 To 712.
 
Paper: 

NOVEL TRENDS IN GENETICS: TRANSPOSABLE ELEMENTS AND THEIR APPLICATION IN MEDICINE

 
DOI: 

0141710/AIM.0012

 
Author(s):  VAND RAJABPOUR FATEMEH, RAOOFIAN REZA, HABIBI LALEH, AKRAMI SEYED MOHAMMAD, TABRIZI MINA*
 
* DEPARTMENT OF MEDICAL GENETICS, SCHOOL OF MEDICINE, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN 14176-13151, IRAN
 
Abstract: 

Forty-five percent of the human genome is composed of Transposable Elements (TEs); therefore، TEs have had an undisputed impact on evolution of the most evolved creature by a very simple mechanism of action. Scientists have been studying this simple mechanism of action and are currently using it to develop efficient and safe gene delivery systems especially for treatment of diseases. TEs have also been used safely in generating induced Pluripotent Stem Cells (iPSC) for regenerative medicine، which opens the door to a world of possibilities in our approach in trying to wrestle with many challenges in medicine. The PiggyBac (PB) system has yielded more success in generation of induced pluripotent stem cells in regenerative medicine، and the Sleeping Beauty (SB) has been more successful in Gene Therapy. Recent advances are indicative of more good news to come regarding the potential heights of successes achievable by the use of the TE-based systems.

 
Keyword(s): GENE THERAPY, GENETIC TRANSPOSITION, INDUCED PLURIPOTENT STEM CELL (IPSC), TRANSPOSABLE ELEMENTS (TES), TRANSPOSABLE ELEMENT BASED VECTORS (TEV)
 
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