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Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   OCTOBER 2014 , Volume 17 , Number 10; Page(s) 722 To 723.
 
Paper: 

ACUTE BRUCELLOSIS WITH TYPICAL HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS ACCOMPANYING ELEVATED TUMOR MARKERS (CASE REPORT)

 
 
Author(s):  YIN XIUYUN, LI YUHANG, ZENG LIJUN, YU NONG, SONG SHIPING, ZHANG WEI, CHEN JIANKUI, WANG JUN, HU LIANGDING*, CHEN SHUIPING*
 
* DEPARTMENT OF LABORATORY MEDICINE, AFFILIATED HOSPITAL OF ACADEMY OF MILITARY MEDICAL SCIENCES, NO. 8, DONGDAJIE ST, FENGTAI DIST, BEIJING 100071, CHINA
 
Abstract: 

We reported a typical brucellosis, which was diagnosed as hemophagocytic lymphohistiocytosis (HLH). Although some tumor markers (CEA, CYFRA21-1, NSE, CA19-9) in the patient’s serum were elevated, carcinomas were excluded by a variety of inspections including bone marrow aspirations, ultrasound examinations, and whole-body PET-CT scans. It was concluded that serum tumor markers are considered medically necessary as a screening test for brucellosis with HLH, however, detailed inspections were needed to make a final diagnosis. Moreover, combination of epidemiology investigations and laboratory inspections were helpful to determine the etiology of HLH and initiate the corresponding treatments.

 
Keyword(s): BRUCELLA, HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, TUMOR MARKERS
 
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