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Paper Information

Journal:   JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS   AUGUST 2014 , Volume 9 , Number 3; Page(s) 0 To 0.
 
Paper: 

INHIBITORY EFFECT OF BERBERIS VULGARIS AQUEOUS EXTRACT ON ACQUISITION AND REINSTATEMENT EFFECTS OF MORPHINE IN CONDITIONED PLACE PREFERENCES (CPP) IN MICE

 
 
Author(s):  IMENSHAHIDI MOHSEN, QAREDASHI REZA, HASHEMZAEI MAHMOUD, HOSSEINZADEH HOSSEIN*
 
* PHARMACEUTICAL RESEARCH CENTER, SCHOOL OF PHARMACY, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IR IRAN
 
Abstract: 

Background: It has been elucidated that Berberis vulgaris (barberry) can alleviate morphine withdrawal syndrome. Also it has been reported that aqueous extract of barberry possibly have inhibitory effect on NMDA receptors.
Objectives: In this study, we decided to evaluate the effects of aqueous extract of B. vulgaris fruit on morphine tendency in mice using conditioned place preference (CPP) method.
Materials and Methods: In experiment 1 (acquisition phase), mice underwent morphine-induced conditioned place preference (CPP) training with injections of morphine (40 mg/kg). In experiment 2 (extinction and reinstatement phases), mice underwent the same CPP training as in experiment 1 and subsequent extinction training on day 16th a reinstatement by CPP was done by injection of reminding 10 mg/kg morphine.
Results: The administration of morphine (40 mg/kg for four days) produced place preference. In the first method, the aqueous extract of barberry (200 mg/kg) prevented morphine tendency to white cell in CPP method. In the second method, after inter-peritoneal injection of aqueous extracts of barberry at 100 and 200 mg/kg, the animals tendency toward the white cells of CPP chamber on the sixteenth day (after a reminder injection of morphine 10 mg/kg) was significantly reduced.
Conclusions: These results show that aqueous extract of barberry can reduce the acquisition and reinstatement of morphine-induced conditioned place preference.

 
Keyword(s): BERBERIS VULGARIS, WITHDRAWAL SYNDROME, MORPHINE, METHODS
 
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