Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS   AUGUST 2014 , Volume 9 , Number 3; Page(s) 0 To 0.
 
Paper: 

DESIGN AND EVALUATION OF SELF-EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS) OF CARVEDILOL TO IMPROVE THE ORAL ABSORPTION

 
 
Author(s):  SALIMI ANAYATOLLAH*, SHARIF MAKHMALZADEH BEHZAD, HEMATI ALI ASGHAR, AKBARI BIRGANI SANAZ
 
* DEPARTMENT OF PHARMACEUTICS, NANOTECHNOLOGY RESEARCH CENTER, AHVAZ JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES, AHVAZ, IR IRAN
 
Abstract: 

Background: Self-emulsifying drug delivery system is an isotropic mixture of natural or synthetic oils, non-ionic surfactants or, one or more hydrophilic solvent and co-solvents/surfactant and polymer that improve bioavailability and increase solubility of poorly-soluble drugs.
Objectives: This study was aimed to prepare and develop a stable formulation for self-emulsifying drug delivery system to enhance the solubility, release rate, and oral absorption of the poorly-soluble drug, carvedilol.
Materials and Methods: The prepared self-emulsifying drug delivery system formulations were evaluated regarding their particle size, refractory index (RI), emulsifying efficiency, drug release, and rat intestine permeability.
Results: The results showed oleic acid as oil with Labrafil as surfactant and Labrafac PG (propylene glycol dicaprylocapraye) as cosurfactant with hydroxypropyl methylcellulose and Poloxamer as polymer prepared stable emulsions with a refractive index higher than acidic medium and water. The particle size of formulations was influenced by the type of polymer so that the mean particle size in the self-emulsifying drug delivery system formulations containing hydroxypropyl methylcellulose have a higher particle size compared to Poloxamer formulations. The percentage of drug release after 24 hours (R24) for Poloxamer and hydroxypropyl methylcellulose formulations were 61.24-70.61% and to 74.26-91.11%, respectively. The correlation between percentages of drug released after 24 hours with type of polymer was significant. In permeation studies, a significant and direct correlation existed between P4 and surfactant/cosurfactant ratio. The self-emulsifying drug delivery system formulations showed drug permeability through the rat intestine 2.76 times more, compared with the control.
Conclusions: This study demonstrated that physicochemical properties, in vitro release and rat intestine permeability were dependent upon the contents of S/C, water and oil percentage in formulations.

 
Keyword(s): CARVEDILOL, SELF-EMULSIFYING DRUG DELIVERY SYSTEMS, ORAL ABSORPTION
 
References: 
  • ندارد
 
  pdf-File tarjomyar Yearly Visit 70
 
Latest on Blog
Enter SID Blog