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Paper Information

Journal:   JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS   AUGUST 2014 , Volume 9 , Number 3; Page(s) 0 To 0.
 
Paper: 

WOUND HEALING POTENTIAL OF TOPICAL AMLODIPINE IN FULL THICKNESS WOUND OF RABBIT

 
 
Author(s):  HEMMATI ALI ASGHAR, MOJIRI FORUSHANI HODA*, MOHAMMAD ASGARI HOSSEIN
 
* SCHOOL OF PHARMACY, PHYSIOLOGY RESEARCH CENTER, AHVAZ JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES, AHVAZ, IR IRAN
 
Abstract: 

Background: Wound healing is a complicated and integrated process. Researches have indicated the wound healing effects of calcium channel blockers in animal models in recent years.
Objectives: The aim of this study was to evaluate the wound-healing activity of amlodipine as a calcium channel blocker and combination of amlodipine with phenytoin on excisional cutaneous wound models in rabbit.
Materials and Methods: Animals were divided into 5 groups (n=5). The control group was treated topically with eucerin. The untreated control group received no healing agent. The reference standard group was treated with phenytoin 1%. A treatment group was treated with amlodipine 1%. The last group was treated with combination of amlodipine 1% and phenytoin 1%.
Results: Results indicated significant difference between days needed for complete healing in both of the treatment groups. Wound closure was completed on 13th day and 9th day in amlodipine and combination groups respectively.
Conclusions: In conclusion, calcium channel blockers can be used to enhance wound healing, especially if this treatment becomes with phenytoin. Further studies are needed to find out the mechanism of this healing effect.

 
Keyword(s): WOUND HEALING, CALCIUM CHANNEL BLOCKER, AMLODIPINE, PHENYTOIN, RABBITS
 
References: 
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