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Paper Information

Journal:   JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS   AUGUST 2014 , Volume 9 , Number 3; Page(s) 0 To 0.
 
Paper: 

CHEMICAL COMPOSITION, MODULATORY BACTERIAL RESISTANCE AND ANTIMICROBIAL ACTIVITY OF ESSENTIAL OIL THE HYPTIS MARTIUSII BENTH BY DIRECT AND GASEOUS CONTACT

 
 
Author(s):  LEITE DE OLIVEIRA ALLAN DEMETRIUS, GALVAO RODRIGUE FABIOLA FERNANDES, MELO COUTINHO HENRIQUE DOUGLAS*, MARTINS DA COSTA JOSE GALBERTO, ALENCAR DE MENEZES IRWIN ROSE
 
* DEPARTMENT OF BIOLOGICAL CHEMISTRY, UNIVERSITY OF CARIRI REGIONAL-URCA, CRATO-CE, BRAZIL
 
Abstract: 

Background: Several studies have shown that species of the genus Hyptis, have promising antimicrobial and antifungal effects. Objectives: Identify of chemical constituents of essential oil from leaves of Hyptis martiusii and evaluate its effect against bacterial strains by direct and gaseous contact.
Materials and Methods: Essential oil was extracted from leaves of Hyptis martiusii Benth using hydro-distillation, and its composition was determined using gas chromatography–mass spectrometry (GC-MS). Chemical analysis showed that there was a predominance of sesquiterpenes. The leaf essential oil was screened for its minimal inhibitory concentration and modulatory effect of aminoglycoside by the direct (MIC) and gaseous (MID) micro-dilution assays for various pathogenic microorganisms. The essential oil remarkably inhibited the growth of all of the tested bacteria (MIC<512
mg/mL) except S. aureus (SA358) multidrug resistant (MRSA) by direct contact.
Results: Twenty-four compounds representing 92.13% of the essential oil of leaves were characterized;
d -3-carene (6.88%), 1, 8-cineole (7.01%), trans-caryophyllene (9.21%), Cariophyllene oxide (7.47%) and bicyclogermacrene (10.61%) were found as the major components. Modulatory aminoglycoside effect, by direct contact, was showed antagonistic relationship with antimicrobial activity. The gaseous component of the oil inhibited the bacterial growth of all of the tested bacteria in 50% and 25% of oil concentration and demonstrated synergistic interactions can be attributed to the constituting the oil compounds.
Conclusions: These results show that this oil influences the activity of the antibiotic and may be used as an adjuvant in the antibiotic therapy of respiratory tract bacterial pathogens.

 
Keyword(s): ESSENTIAL OILS, HYPTIS MARTIUSII, ANTIMICROBIAL RESISTANCE, AMINOGLYCOSIDE
 
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