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Paper Information

Journal:   MODERN GENETICS JOURNAL (MGJ)   SUMMER 2012 , Volume 7 , Number 2 (29); Page(s) 141 To 145.
 
Paper: 

STUDY ABCG2 GENE POLYMORPHISM IN IRANIAN HOLSTEIN BULLS

 
 
Author(s):  MOUSAVIZADEH ALI, SALEHI ABDOLREZA*, AMINAFSHAR MEHDI, NAZEMSHIRAZI MOHAMMADHOSSEIN
 
* ANIMAL AND POULTRY SCIENCE DEPARTMENT, UNIVERSITY OF TEHRAN, ABURAIHAN CAMPUS, IRAN
 
Abstract: 

ABCG2 (ATP binding cassette subfamily G member 2) gene have located in chromosome 6 which is encoded ABCG2 protein that transports various xenobiotics, cytostatic drugs across the plasma membrane and cholesterol into milk. A single nucleotide change (A/C) in base 86 of exon 14 is capable of encoding a substitution of tyrosine to serine in the ABCG2 gene and increases milk yield and decreases fat and protein concentration. The major aim of this research is to identify ABCG2 gene polymorphism in Iranian population of Holstein bulls. Genomic DNA of 105 bulls was extracted from semen samples using high Pure PCR template preparation kit. Primers were designed with Oligo software and utilized in PCR. Then the PCR fragments were sequenced. Results of sequences were compared with NCBI sequence databases. A/C mutation in base 86 of exon 14 was observed with 2% frequency.
ABCG2 gene, Iranian Holstein bulls, Polymorphism.

 
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