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Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   OCTOBER 2014 , Volume 17 , Number 10; Page(s) 685 To 691.
 
Paper: 

GENETIC VARIABILITY OF CYP2B6 POLYMORPHISMS IN SOUTHEAST IRANIAN POPULATION: IMPLICATIONS FOR MALARIA AND HIV/AIDS TREATMENT

 
DOI: 

0141710/AIM.009

 
Author(s):  ZAKERI SEDIGHEH*, AMIRI NASRIN, PIRAHMADI SAKINEH, DINPARAST DJADID NAVID
 
* MALARIA AND VECTOR RESEARCH GROUP (MVRG), BIOTECHNOLOGY RESEARCH CENTER (BRC), PASTEUR INSTITUTE OF IRAN, PASTEUR AV.,TEHRAN, IRAN
 
Abstract: 

BACKGROUND: Genetic polymorphisms in the cytochrome P450 2B6 (CYP2B6) gene could influence therapeutic outcomes of CYP2B6-metabolized drugs such as artemisinin, nevirapine (NVP), and efavirenz (EFV). The main objective of the present study was to analyze the frequency of the most common allele of CYP2B6*1 to *7 and *9 in Iranian Baluchi population and also to compare the frequencies of these polymorphisms with those reported in different ethnic groups.
METHODS: A total of 206 healthy, unrelated, subjects were participated in this study. CYP2B6*1, *2, *3, *4, *5, *6,*7, and *9 polymorphisms were investigated, using PCR-RFLP followed by sequencing analysis.
RESULTS: High frequency of 516T (35.7%) was found among the studied subjects. Also, the three most frequent genotypes were CYP2B6*1/*6 (28.1%), CYP2B6*1/*1 (16%) and CYP2B6*1/*9 (14.6%). The frequency of CYP2B6*6/*6 (4.8%) was not different from Caucasian, Japanese and Chinese populations, but it was lower than West African (17%) and Papua New Guinean (43%) populations.
CONCLUSION: Allele frequencies for CYP2B6 in the examined population were markedly different from those African, Caucasian, and Southeast Asian populations. CYP2B6*2, *4, *5, *6, and *7 were found in the Iranian Baluchi that may affect the response to artemisin and its derivatives. High frequency of G516T (35.7%) was detected among the examined subjects that might cause greater efavirenz plasma exposure and more central nervous system side effects. Therefore, characterization of pharmacologically relevant polymorphisms in CYP2B6 has a great potential to improve drug efficacy and reduce toxicity.

 
Keyword(s): ALLELE FREQUENCY, CYTOCHROME P450 2B6, GENETIC POLYMORPHISMS, SOUTHEAST IRAN
 
References: 
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