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Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   NOVEMBER 2013 , Volume 16 , Number 11; Page(s) 652 To 656.
 
Paper: 

ARDEH (SESAMUM INDICUM) COULD IMPROVE SERUM TRIGLYCERIDES AND ATHEROGENIC LIPID PARAMETERS IN TYPE 2 DIABETIC PATIENTS: A RANDOMIZED CLINICAL TRIAL

 
DOI: 

0131611/AIM.008

 
Author(s):  MIRMIRAN PARVIN, BAHADORAN ZAHRA, GOLZARAND MAHDIEH, RAJAB ASADOLAH, AZIZI FEREIDOUN*
 
* ENDOCRINE RESEARCH CENTER, RESEARCH INSTITUTE FOR ENDOCRINE SCIENCES, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN. ADDRESS: NO. 24, PARVANEH ST., YEMEN ST., CHAMRAN EXP., TEHRAN, IRAN
 
Abstract: 

BACKGROUND: Data suggest that sesame seeds have properties beneficial to modulating lipid disorders and decreasing cardiovascular disease (CVD) risk factors. The aim of this study was to investigate the effects of Ardeh, paste of ground unhulled sesame seeds, on lipid profiles and atherogenic lipid parameters.
METHODS: This randomized clinical trial included 41 patients with type 2 diabetes, who were randomly assigned to one of the two groups: group A (Ardeh 28 g/d, n=21) and group B (control, n=20). After an initial two-week washout period, the patients in group A, replaced a part of their usual breakfast with two tablespoon (tbsp) (
~28 g) Ardeh, while group B patients continued the usual breakfast meal for six weeks; energy content of both breakfast meals was maintained in the same range. Anthropometric measures, blood pressure, serum levels of total cholesterol (TC), triglycerides (TG), LDL-C, HDL-C, and atherogenic index of plasma (AIP; log TG/HDL-C), TC/HDL-C ratio, and LDL/HDL-C ratio were determined at baseline and six weeks later.
RESULTS: After six weeks, there were significant decreases in serum TG (15.3 mg/dL) and AIP (39%) in group A. Moreover, slight decreases in serum TC, LDL-C, and other atherogenic lipid parameters and a mild increase in HDL-C also were observed during Ardeh supplementation. Anthropometric measures and blood pressure were unchanged during the study period in both groups.
CONCLUSION: Ardeh could have favorable effects in decreasing CVD risk factors in type 2 diabetics.

 
Keyword(s): ARDEH, LIPID PROFILES, SESAME SEEDS, TYPE 2 DIABETES
 
References: 
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