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Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   NOVEMBER 2013 , Volume 16 , Number 11; Page(s) 631 To 635.
 
Paper: 

UNSUSPECTED GALLBLADDER CANCER: A CLINICAL RETROSPECTIVE STUDY

 
DOI: 

0131611/AIM.004

 
Author(s):  HU LIANGSHUO, BO WANG, LIU XUEMIN, LV YI*
 
* DEPARTMENT OF HEPATOBILIARY AND PANCREAS SURGERY, THE FIRST AFFILIATED HOSPITAL, MEDICAL COLLEGE OF XI’AN JIAOTONG UNIVERSITY, XI’AN, SHAANXI, CHINA. ADDRESS: NO 277 YANTA WEST ROAD, XI’AN, 710061, CHINA
 
Abstract: 

BACKGROUND: The morbidity of unsuspected gallbladder carcinoma (UGC) has increased. This study was aimed to explore the factors which may influence the therapeutic strategies and prognosis of UCG. Additionally, long-term prognosis of laparoscopic and open surgeries of UGC was comparatively investigated.
METHODS: Thirty-eight cases of UGC were enrolled in this study. Statistical analysis of survival was performed using the Kaplan–Meier test and the results were examined using the log-rank test.
RESULTS: The morbidity of UGC was 0.43%. The cancer stagings were: pT1a (one), pT1b (11), pT2 (14), pT3 (10), pT3N1 (one), and pT4 (one). The median lifespan of the entire cohort was 20.0±6.5 months, one-year survival rate was 44%, and five-year survival rate was 11 %. One-year recurrence- free survival rate was 44% and three-year recurrence- free survival rate was 0 %. Twenty-eight patients sustained cancer recurrence and three patients sustained port-site cancer recurrence. The cancer staging (P<0.01) and radical resection (P<0.01) were independent factors for both overall and recurrence-free survival. Radical resection improved the prognosis of the patients with pT2 stage UGC (P<0.05), but no significant impact on the prognosis of the patients with pT1b (P=0.362) or pT3 stage (P=0.221) UGC. Survival rates were not significantly affected by the first operation no matter it was laparoscopic surgery or open surgery (P=0.12).
CONCLUSION: Radical resection surgery is recommended in pT2 stage UGC. There is no difference for the long-term prognosis between laparoscopic surgery (cholecystectomy) and open surgery of UCG.

 
Keyword(s): LAPAROSCOPIC CHOLECYSTECTOMY, OPEN CHOLECYSTECTOMY, UNSUSPECTED GALLBLADDER CARCINOMA
 
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