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Paper Information

Journal:   JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS   FEBRUARY 2014 , Volume 9 , Number 1; Page(s) 16 To 23.
 
Paper: 

TOXICITY EVALUATION OF MICRO EMULSION (NANO SIZE) OF SOUR CHERRY KERNEL EXTRACT FOR THE ORAL BIOAVAILABILITY ENHANCEMENT

 
 
Author(s):  SALIMI ANAYATOLLAH, MOTAHARITABAR EISA, GOUDARZI MEHDI, REZAIE ANNAHITA, KALANTARI HEIBATULLAH*
 
* DEPARTMENT OF PHARMACOLOGY AND TOXICOLOGY, SCHOOL OF PHARMACY, AHVAZ JUNDISHPUR UNIVERSITY OF MEDICAL SCIENCES, AHVAZ, IR IRAN
 
Abstract: 

Background: In the recent years nanostructured materials have been the focus of researches due to their wide-spread possibilities to provide new shapes and structures for some materials. Micro emulsions can provide uniform nano-sized droplets for templating. Micro emulsions are isotropic, thermodynamically-stable systems of oil, water and surfactant with a 20-200 nm droplet size. They can be prepared as oil-in-water (o/w), water-in-oil (w/o) or bicontinuous systems, depending on the equilibrium spontaneous curvature of the surfactant layer at the oil-water interface.
Objectives: The aim of this study was to introduce a system designed to improve and enhance the bioavailability of bioflavonoids in the Prunus cerasus (sour cherry) seed kernel extract by developing a novel delivery system, i.e. micro emulsion (nanosized particles).
Materials and Methods: Micro emulsion formulations were prepared by mixing appropriate amounts of surfactants (Tween 80 and Span 20), cosurfactant (propylene glycol) (3:1 ratio), and oil phase (olive oil). The prepared micro emulsions were evaluated regarding their mean droplet size, transparency, viscosity, and pH. Sour cherry kernel extract micro emulsion was orally administered to mice at doses of 2.5%, 5%, and 10% for 10 days. On the last day, their blood as well as their liver and kidney were used for biochemical and histopathological analyses, respectively.
Results: Biochemical factors levels and the pathological study indicated that there were not significant differences in micro emulsion extracts compared with the control group (P
>0.05).
Conclusions: Not only no toxicity evidence of this product was observed in the dose range used in foods or healthcare, but also it improved the cardiac function recovery.

 
Keyword(s): TOXICITY, BIOLOGICAL AVAILABILITY, BIOLOGICAL AVAILABILITY
 
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