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Paper Information

Journal:   IRANIAN JOURNAL OF PUBLIC HEALTH   AUGUST 2014 , Volume 43 , Number SUPPLEMENT 2; Page(s) 75 To 75.
 
Paper: 

IN VITRO INHIBITORY ACTIVITY OF ODONTOBUTHUS DORIAE SCORPION VENOM AGAINST STAPHYLOCOCCUS AUREUS

 
 
Author(s):  ZAYERZADEH EHSAN*
 
* DEPARTMENT OF BIOLOGY, FOOD INDUSTRY AND AGRICULTURE RESEARCH CENTER, STANDARD RESEARCH INSTITUTE, KARAJ, IRAN
 
Abstract: 

Background: Microbial antibiotic resistance is a challenging medical problem nowadays. Then, it is of considerable interest to develop antibiotics with a new mechanism of action, which can potentially evade the emergence of drug resistance. In the search for such new agents, we are looking for effective antibacterial natural venoms that have potential activity against Staphylococcus aureus and Escherichia coli.
Methods: In our investigation, we studied the antibacterial effects of Odontobuthus doriae scorpion venom against Staphylococcus aureus and Escherichia coli bacterial strains. Several concentrations (1, 5, 10, 20, 40 and 80
mg/ml) of crude venom were tested for antibacterial activity against Staphylococcus aureus and Escherichia coli by disc-diffusion susceptibility at different time intervals.
Results: All of the concentrations of crude venom have significant antibacterial effects against Staphylococcus aureus after 48 h of incubation; while Odontobuthus doriae concentrations have no antibacterial effects on Escherichia coli.
Conclusion: In conclusion, our findings demonstrated Odontobuthus doriae scorpion venom has an antibacterial activity against Staphylococcus aureus and could be used as a new drug for disease induced by Staphylococcus aureus.

 
Keyword(s): ANTIBACTERIAL ACTIVITY, STAPHYLOCOCCUS AUREUS, ESCHERICHIA COLI
 
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