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Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   DECEMBER 2013 , Volume 16 , Number 12; Page(s) 725 To 730.
 
Paper: 

EXFOLIATIVE CYTOLOGY OF ORAL MUCOSA AMONG SMOKERS, OPIUM ADDICTS AND NON-SMOKERS: A CYTOMORPHOMETRIC STUDY

 
DOI: 

0131612/AIM.008

 
Author(s):  HASHEMIPOUR MARYAM ALSADAT*, AGHABABAIE MAHBOBEH, REZA MIRSHEKARI TORAJ, ASADI SHEKAARI MAJID, TAHMASBI ARASHLOW MEHRNAZ, TAHMASBI ARASHLOW FARZAD, GANDJALIKHAN NASSAB SAYED AMIR HOSSEIN
 
* DEPARTMENT OF ORAL MEDICINE, SCHOOL OF DENTISTRY, KERMAN UNIVERSITY OF MEDICAL SCIENCES, KERMAN, IRAN
 
Abstract: 

BACKGROUND: The present study was conducted to evaluate keratinization as well as nuclear and cytoplasmic changes of oral epithelial cells among smokers, opium addicts and non-smokers through exfoliative cytology technique.
METHODS: Smears of buccal mucosa and mouth floor were collected from 300 males (100 smokers, 100 opium addicts and 100 non-smokers). The nucleus and cytoplasm sizes were determined using image analysis software. Data was analyzed with Mann-Whitney test and Student’s t-test on SPSS version 13 statistical software. Statistical significance was defined as P<0.05.
RESULTS: The results revealed statistically significant differences in cellular and nuclear size and the nuclear/cytoplasmic ratio between smokers, opium addicts and non-smokers in different age groups. The mean size of the nucleus compared to that of cytoplasm was significantly higher in smokers and opium addicts compared to non-smokers after correction for age.
CONCLUSION: The results of this study indicate different rates of epithelial cell keratinization in oral cavity among smokers, opium addicts and non-smokers. Also, our results suggest a possible relationship between the number of cigarettes per day, daily opium consumption and an increase in the rate of cellular proliferation of oral mucosal cells. The present study indicated a decrease in cellular diameter as well as an increase in nuclear diameter and nuclear/cytoplasmic ratio in smears taken from both smokers and opium addicts compared to non-smokers.

 
Keyword(s): CYTOLOGY, EXFOLIATIVE, NUCLEAR, OPIUM, SMOKING
 
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