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Paper Information

Journal:   HEPATITIS MONTHLY   APRIL 2014 , Volume 14 , Number 4; Page(s) 0 To 0.
 
Paper: 

EVALUATION OF THE RELATION BETWEEN HEPATIC FIBROSIS AND BASIC LABORATORY PARAMETERS IN PATIENTS WITH CHRONIC HEPATITIS B FIBROSIS AND BASIC LABORATORY PARAMETERS

 
 
Author(s):  DEMIR NAZLIM AKTUG, KOLGELIER SERVET, OZCIMEN SERAP, GUNGOR GOKHAN, SUMER SUA*, DEMIR LUTFI SALTUK, INKAYA AHMET CAGKAN, URAL ONUR
 
* INFECTIOUS DISEASES AND CLINICAL MICROBIOLOGY DEPARTMENT, SELCUK UNIVERSITY, KONYA, TURKEY
 
Abstract: 

Background: The hepatitis B virus is an important healthcare problem. According to current clinical practice, a liver biopsy is required for the diagnosis and treatment of chronic liver disease. However, a liver biopsy is an invasive, inconvenient procedure, which requires an expert pathologist opinion. Therefore requirement of biochemical tests, which are considered to indicate hepatic fibrosis and may be repeated easily, increases gradually today.
Objectives: This study evaluated the correlation between hepatic fibrosis and routine laboratory values in patients with chronic hepatitis B.
Patients and Methods: The files of 456 patients with CHB (chronic hepatitis B) who were referred to the infectious diseases and clinical microbiology clinic between January 2009 and March 2012 were screened retrospectively. Liver biopsy samples were examined according to Ishak scoring. Laboratory parameters and histopathology reports were recorded, and correlations between the fibrosis grade and laboratory parameters were analyzed.
Results: There were 320 male and 136 female patients, with a mean age 36.7±12.1 years. According to liver biopsy results, a low fibrosis score (stage 0-2) was detected in 281 patients (61.6%), and a high fibrosis score (stage 3-5) was detected in 175 patients (38.4%). Patients with a high fibrosis score had significantly higher ALT (alanine amino transferase), AST (aspartate aminotransferase), and HBV-DNA values and a significantly lower platelet count compared with those with a low fibrosis score (P=0.001, 0.001, 0.025, and 0.001, respectively). A positive correlation was detected between the fibrosis score and age, BMI, HAI, ALT, and AST values, and a negative correlation was detected between the fibrosis score and albumin and platelet counts. In the regression analysis performed to evaluate the factors associated with high-stage fibrosis, fibrosis was determined to be associated with thrombosis, ALT, and gender. The results of the regression analysis demonstrated that the risk of fibrosis was 4.6 fold higher in men.
Conclusions: According to the results obtained in our study, advanced age, higher BMI, AST, ALT, and HBV-DNA levels, and low albumin and platelet levels are correlated with advanced fibrosis in patients with CHB.

 
Keyword(s): HEPATITIS B, CHRONIC, BIOLOGICAL MARKERS, LIVER CIRRHOSIS
 
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