Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   DECEMBER 2013 , Volume 16 , Number 12; Page(s) 711 To 716.
 
Paper: 

CANNABINOID SYSTEM OF THE LATERAL SEPTUM IN THE MODULATION OF ANXIETY-LIKE BEHAVIORS IN RATS

 
DOI: 

0131612/AIM.006

 
Author(s):  HAJIZADEH MOGHADDAM AKBAR*, BIGDELLU RATA, FATEMI TABATABAEI SEYED REZA, ROOHBAKHSH ALI
 
* DEPARTMENT OF BIOLOGY, FACULTY OF BASIC SCIENCE, UNIVERSITY OF MAZANDARAN, BABOLSAR, IRAN
 
Abstract: 

BACKGROUNDS: A large body of evidence suggests that the cannabinoid CB1 receptor plays a key role in the regulation of emotional behaviors. The present study was designed to evaluate the effects of CB1 agonist and antagonist on anxiety-like behaviors in the lateral septum (LS) region of the rat brain using elevated plus maze test.
METHODS: Rats were anesthetized with ketamine and xylazine and special cannulas were inserted stereotaxically into the LS region. After 1 week of recovery, the effects of intra-LS administration of the CB1 receptor agonist, WIN 55,212-2 and CB1 receptor antagonist, AM251, on %OAT and %OAE were measured. Moreover, the effects of pretreatment with AM251 on the response induced by intra-LS administration of WIN 55,212-2 were also assessed.
RESULTS: Intra-LS administration of WIN 55,212-2 (0.001, 0.005 and 0.5
mg/rat) decreased the %OAT and %OAE but not locomotor activity, showing an anxiogenic-like response. Intra-LS injection of different doses of AM251 (0.001, 0.01 and 0.1 mg/rat) did not significantly alter the anxiety-like parameters on the plus-maze test. However, intra-LS injections of AM251 (0.01 mg/rat) significantly reversed WIN 55,212-2-induced anxiogenic-like effects.
CONCLUSIONS: The results suggest that the cannabinoid system of the lateral septum modulates anxiety-like behavior through CB1 receptor.

 
Keyword(s): ANXIETY, CANNABINOID, LATERAL SEPTUM, PLUS-MAZE TEST, RAT
 
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