Paper Information

Journal:   HEPATITIS MONTHLY   APRIL 2014 , Volume 14 , Number 4; Page(s) 0 To 0.
 
Paper: 

ALANINE AMINOTRANSFERASE ELEVATION IN OBESE INFANTS AND CHILDREN: A MARKER OF EARLY ONSET NON ALCOHOLIC FATTY LIVER DISEASE

 
 
Author(s):  ENGELMANN GUIDO*, HOFFMANN GEORG FRIEDRICH, GRULICH HENN JUERGEN, TEUFEL ULRIKE
 
* DEPARTMENT OF PEDIATRICS, LUKAS HOSPITAL, PREUSSEN STR 84, D-41464 NEUSS, GERMANY
 
Abstract: 

Background: Elevated aminotransferases serve as surrogate markers of non-alcoholic fatty liver disease, a feature commonly associated with the metabolic syndrome. Studies on the prevalence of fatty liver disease in obese children comprise small patient samples or focus on those patients with liver enzyme elevation.
Objectives: We have prospectively analyzed liver enzymes in all overweight and obese children coming to our tertiary care centre.
Patients and Methods: In a prospective study 224 healthy, overweight or obese children aged 1 - 12 years were examined. Body Mass Index-Standard Deviation Score, alanine aminotransferase, aspartate aminotransferase and gamma-glutamyl-transpeptidase were measured.
Results: Elevated alanine aminotransferase was observed in 29% of children.26 % of obese and 30 % of overweight children had liver enzyme elevations. Obese children had significantly higher alanine aminotransferase levels than overweight children (0.9 vs.0.7 times the Upper Limit of Normal; P=0.04).
Conclusions: Elevation of liver enzymes appears in 29 % obese children in a tertiary care centre. Absolute alanine aminotransferase levels are significantly higher in obese than in overweight children. Even obese children with normal liver enzymes show signs of fatty liver disease as demonstrated by liver enzymes at the upper limit of normal.

 
Keyword(s): LIVER; OBESITY, FATTY LIVER, NON-ALCOHOLIC FATTY LIVER DISEASE, CHILD
 
References: 
  • ندارد
 
  pdf-File tarjomyar Yearly Visit 77
 
Latest on Blog
Enter SID Blog