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Paper Information

Journal:   JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS   2013 , Volume 8 , Number 1; Page(s) 27 To 33.
 
Paper: 

THE USE OF NATURAL BIOPOLYMER OF CHITOSAN AS BIODEGRADABLE BEADS FOR LOCAL ANTIBIOTIC DELIVERY: RELEASE STUDIES

 
 
Author(s):  JEBRAEEL MOVAFFAGH, GHODSI ALI, FAZLY BAZZAZ BIBI SEDIGHEH, SAJADI TABASSI SAYYED ABOLGHASSEM*, GHODRATI AZADI HAMIDEH
 
* PHARMACOLOGICAL RESEARCH CENTER OF MEDICINAL PLANTS, SCHOOL OF MEDICINE, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IR IRAN
 
Abstract: 

Background: Chitosan is a naturally occurring biopolymer which has been widely used in a variety of biomedical applications including local antibiotic delivery due to its excellent mechanical properties, biodegradability and biocompatibility. Beads are spherical, porous carriers which are prepared from various materials including chitosan.
Objectives: The current study aimed to fabricate a new controlled delivery system for local anti-infective treatment and to study its release behavior.
Materials and Methods: Twenty beads were prepared from 1% or 2% chitosan solutions and immersed in vancomycin (VM) or teicoplanin (TN) solutions. The antibiotic release kinetics was determined by linear regression analysis supposing first order kinetics.
Results: Immersion for 3 h resulted in significant increase in the total TN release that differed from 0.5 h of immersion, except for the 1% beads immersed in VM. Increasing the chitosan concentration significantly increased the total release and antibiotic load of beads. The release of TN was more delayed compared to that of VM, which allowed a gradual release beyond 3 days. The half-life (mean
±SEM) of both types of TNcontaining beads was significantly extended for 3 h immersion in comparison to 0.5 h immersion (26.1±5.9 vs 10.9±1.0 and 17.0±2.1 vs 5.1±1.9, P<0.001). However, neither increasing the chitosan concentration, nor immersion time did result in any significant increase in the release of VM.
Conclusions: The current study demonstrated an improved control of TN release impregnated in beads. It can be concluded that chitosan beads might be considered as a novel carrier for TN delivery to infected bone for local anti-infective therapy.

 
Keyword(s): DELAYED-ACTION PREPARATIONS, TEICOPLANIN, CHITOSAN, CROSS-LINKING REAGENTS
 
 
References: 
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APA: Copy

JEBRAEEL, M., & GHODSI, A., & FAZLY BAZZAZ, B., & SAJADI TABASSI, S., & GHODRATI AZADI, H. (2013). THE USE OF NATURAL BIOPOLYMER OF CHITOSAN AS BIODEGRADABLE BEADS FOR LOCAL ANTIBIOTIC DELIVERY: RELEASE STUDIES. JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS, 8(1), 27-33. https://www.sid.ir/en/journal/ViewPaper.aspx?id=411028



Vancouver: Copy

JEBRAEEL MOVAFFAGH, GHODSI ALI, FAZLY BAZZAZ BIBI SEDIGHEH, SAJADI TABASSI SAYYED ABOLGHASSEM, GHODRATI AZADI HAMIDEH. THE USE OF NATURAL BIOPOLYMER OF CHITOSAN AS BIODEGRADABLE BEADS FOR LOCAL ANTIBIOTIC DELIVERY: RELEASE STUDIES. JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS. 2013 [cited 2021November27];8(1):27-33. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=411028



IEEE: Copy

JEBRAEEL, M., GHODSI, A., FAZLY BAZZAZ, B., SAJADI TABASSI, S., GHODRATI AZADI, H., 2013. THE USE OF NATURAL BIOPOLYMER OF CHITOSAN AS BIODEGRADABLE BEADS FOR LOCAL ANTIBIOTIC DELIVERY: RELEASE STUDIES. JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS, [online] 8(1), pp.27-33. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=411028.



 
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