Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS   2013 , Volume 8 , Number 1; Page(s) 10 To 14.
 
Paper: 

ANTINOCICEPTIVE EFFECT OF HYDROALCOHOLIC EXTRACT OF IRANIAN GREEN TEA IN THE FORMALIN TEST IN RATS

 
 
Author(s):  ARZI ARDESHIR, GHORBANZADEH BEHNAM*, NAZARI KHORASGANI ZAHRA
 
* DEPARTMENT OF PHARMACOLOGY AND TOXICOLOGY, SCHOOL OF PHARMACY, JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES, AHVAZ, IR IRAN
 
Abstract: 

Background: Tea (Camellia sinensis) has been utilised, since time immemorial, as a beverage possessing encouraging health benefits. Little scientific evidence exists in literature on the effect of this plant on pain.
Objectives: To investigate the antinociceptive activity of Iranian green tea extract.
Materials and Methods: The hydroalcoholic extract was administered to male Wistar rats. Formalin paw test was used to evaluate the antinociceptive activity. Plants extract (25, 50, 100 and 200 mg/kg, i.p.) (n=6 for each group) or vehicle (n=6) was administered 30 min before the subplantar formalin injection.
Results: The extract caused a significant dose-related (50, 100, 200 mg /kg, i.p.) inhibition of the first phase and onset of chronic phase (200 mg /kg, i.p.) of formalin induced nociception. The results showed that the pre-treatment of rats with naloxone (1 mg/kg, i.p.) significantly (P<0.001) reversed antinociception by Green tea extract (GTE) (200 mg/kg, i.p.) in the inflammatory phase and had no effect on phase 1.
Conclusions: These results indicate that GTE produces dose-related antinociception in chemical pain model and one of its possible mechanisms involves opioid pathways.

 
Keyword(s): GREEN TEA, ANTINOCICEPTION, FORMALIN TEST, RAT
 
References: 
  • ندارد
 
  pdf-File tarjomyar Yearly Visit 110
 
Latest on Blog
Enter SID Blog