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Paper Information

Journal:   JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS   2013 , Volume 8 , Number 1; Page(s) 10 To 14.
 
Paper: 

ANTINOCICEPTIVE EFFECT OF HYDROALCOHOLIC EXTRACT OF IRANIAN GREEN TEA IN THE FORMALIN TEST IN RATS

 
 
Author(s):  ARZI ARDESHIR, GHORBANZADEH BEHNAM*, NAZARI KHORASGANI ZAHRA
 
* DEPARTMENT OF PHARMACOLOGY AND TOXICOLOGY, SCHOOL OF PHARMACY, JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES, AHVAZ, IR IRAN
 
Abstract: 
Background: Tea (Camellia sinensis) has been utilised, since time immemorial, as a beverage possessing encouraging health benefits. Little scientific evidence exists in literature on the effect of this plant on pain.Objectives: To investigate the antinociceptive activity of Iranian green tea extract.Materials and Methods: The hydroalcoholic extract was administered to male Wistar rats. Formalin paw test was used to evaluate the antinociceptive activity. Plants extract (25, 50, 100 and 200 mg/kg, i.p.) (n=6 for each group) or vehicle (n=6) was administered 30 min before the subplantar formalin injection.Results: The extract caused a significant dose-related (50, 100, 200 mg /kg, i.p.) inhibition of the first phase and onset of chronic phase (200 mg /kg, i.p.) of formalin induced nociception. The results showed that the pre-treatment of rats with naloxone (1 mg/kg, i.p.) significantly (P<0.001) reversed antinociception by Green tea extract (GTE) (200 mg/kg, i.p.) in the inflammatory phase and had no effect on phase 1.Conclusions: These results indicate that GTE produces dose-related antinociception in chemical pain model and one of its possible mechanisms involves opioid pathways.
 
Keyword(s): GREEN TEA, ANTINOCICEPTION, FORMALIN TEST, RAT
 
 
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APA: Copy

ARZI, A., & GHORBANZADEH, B., & NAZARI KHORASGANI, Z. (2013). ANTINOCICEPTIVE EFFECT OF HYDROALCOHOLIC EXTRACT OF IRANIAN GREEN TEA IN THE FORMALIN TEST IN RATS. JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS, 8(1), 10-14. https://www.sid.ir/en/journal/ViewPaper.aspx?id=411018



Vancouver: Copy

ARZI ARDESHIR, GHORBANZADEH BEHNAM, NAZARI KHORASGANI ZAHRA. ANTINOCICEPTIVE EFFECT OF HYDROALCOHOLIC EXTRACT OF IRANIAN GREEN TEA IN THE FORMALIN TEST IN RATS. JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS. 2013 [cited 2021December05];8(1):10-14. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=411018



IEEE: Copy

ARZI, A., GHORBANZADEH, B., NAZARI KHORASGANI, Z., 2013. ANTINOCICEPTIVE EFFECT OF HYDROALCOHOLIC EXTRACT OF IRANIAN GREEN TEA IN THE FORMALIN TEST IN RATS. JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS, [online] 8(1), pp.10-14. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=411018.



 
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