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Paper Information

Journal:   HEPATITIS MONTHLY   APRIL 2014 , Volume 14 , Number 4; Page(s) 0 To 0.
 
Paper: 

PROTECTIVE EFFECT OF CORNUS MAS FRUITS EXTRACT ON SERUM BIOMARKERS IN CCL4 -INDUCED HEPATOTOXICITY IN MALE RATS

 
 
Author(s):  ALAVIAN SEYED MOAYED, BANIHABIB NAFISEH, ESHAGHI MASOUD*, PANAHI FARID
 
* RESEARCH CENTER FOR GASTROENTEROLOGY AND LIVER DISEASE, BAQIYATALLAH UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, I.R. IRAN
 
Abstract: 

Background: Nowadays attention to use herbs such as cornelian cherry (Cornus mas) is increasing, which contains high levels of antioxidants and anthocyanins. Cornus mas fruits have been used for gastrointestinal and excretory disorders for many years in traditional medicine, also may improve liver and kidney functions, and have protective effects such as anti-allergic, antidiabetic, antibacterial, antimicrobial, antihistamine and antimalarial properties.
Objectives: The aim of this study was to investigate protective effects of Cornus mas fruits extract on serum biomarkers in CCl4-induced hepatotoxicity in male rats.
Materials and Methods: Hepatotoxicity was induced by administration of carbon tetrachloride (1 mL/kg i.p.) in 1: 1 dilution with olive oil. To evaluate the effect of Cornus mas fruits extract on disease progression, serum marker enzymes, serum total protein and albumin and liver lipid peroxidation were determined in CCl4-induced hepatotoxicity.
Results: Oral administration of Cornus mas fruits extract to rats for 14 days provided a significant (P<0.05) hepatoprotection by decreasing elevated serum level of enzymes, total serum protein, albumin and liver lipid peroxidation content.
Conclusions: Cornus mas fruit extract effect may be due to including some antioxidant components, which caused membrane stabilizing and normalization of fluctuated biochemical profiles induced by CCl4 exposure. Our results validated the traditional use of Cornus mas in the treatment of liver disorders.

 
Keyword(s): CARBON TETRACHLORIDE, CORNUS MAS, HEPATOTOXICITY, LIPID PEROXIDATION, SERUM BIOMARKERS
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

ALAVIAN, S., & BANIHABIB, N., & ESHAGHI, M., & PANAHI, F. (2014). PROTECTIVE EFFECT OF CORNUS MAS FRUITS EXTRACT ON SERUM BIOMARKERS IN CCL4 -INDUCED HEPATOTOXICITY IN MALE RATS. HEPATITIS MONTHLY, 14(4), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=411017



Vancouver: Copy

ALAVIAN SEYED MOAYED, BANIHABIB NAFISEH, ESHAGHI MASOUD, PANAHI FARID. PROTECTIVE EFFECT OF CORNUS MAS FRUITS EXTRACT ON SERUM BIOMARKERS IN CCL4 -INDUCED HEPATOTOXICITY IN MALE RATS. HEPATITIS MONTHLY. 2014 [cited 2021October16];14(4):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=411017



IEEE: Copy

ALAVIAN, S., BANIHABIB, N., ESHAGHI, M., PANAHI, F., 2014. PROTECTIVE EFFECT OF CORNUS MAS FRUITS EXTRACT ON SERUM BIOMARKERS IN CCL4 -INDUCED HEPATOTOXICITY IN MALE RATS. HEPATITIS MONTHLY, [online] 14(4), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=411017.



 
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