Paper Information

Journal:   IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN)   FALL 2012 , Volume 6 , Number 4; Page(s) 17 To 22.
 
Paper: 

ATYPICAL FINDINGS OF GUILLAIN-BARRE SYNDROME IN CHILDREN

 
 
Author(s):  KARIMZADEH PARVANEH, BAKHSHANDEH BALI MOHAMMAD KAZEM, NASEHI MOHAMMAD MAHDI, TAHERI OTAGHSARA SEYEDEH MOHADESEH, GHOFRANI MOHAMMAD
 
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Abstract: 

Objective: Guillain-Barre syndrome (GBS) is an immune-mediated polyneuropathy that occurs mostly after prior infection. The diagnosis of this syndrome is dependent heavily on the history and examination, although cerebrospinal fluid analysis and electrodiagnostic testing usually confirm the diagnosis.
This is a retrospective study which was performed to investigate the atypical features of GBS.
Materials& Methods: Thirty three patients (21/63.6%males and 12/36.4%females) with GBS were retrospectively studied and prospectively evaluated at the Child Neurology institute of Mofid Children Hospital of Shahid Beheshti University of Medical Sciences between May 2011 and September 2012.
Results: The mean age was 5.4 years (range, 1.5-10.5).Twenty one patients (87.9%) had previous history of infections. Eight patients (24.2%) admitted with atypical symptoms like upper limb weakness (3%), ptosis (3%), neck stiffness (3%), inability to stand (proximal weakness) (9.1%), headache (3%) and dysphagia (3%).According to disease process, weakness was ascending in 26 (78.8%), descending in 5 (15.2%) and static in 2 (6.1%) patients. Cranial nerve involvement was found in 8 (24.3%) children, most commonly as facial palsy in 3 (9.1%).
Conclusion: In this study, 24.3%of our patients presented with atypical symptoms of GBS as upper limb weakness, ptosis, neck stiffness, inability to stand (proximal weakness), headache and dysphagia.

 
Keyword(s): GUILLAIN-BARRE SYNDROME, POLYNEUROPATHY, CEREBROSPINAL FLUID
 
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