Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   JULY 2013 , Volume 16 , Number 7; Page(s) 376 To 379.
 
Paper: 

THE FREQUENCY OF HHV-8 INFECTION IN OTHERWISE HEALTHY BLOOD DONORS AS WELL AS RENAL ALLOGRAFT RECIPIENTS LIVING IN IRAN

 
DOI: 

013167/AIM.003

 
Author(s):  HOSSEINI MOGHADDAM SEYED MOHAMMADMEHDI*, KEYVANI HOSSEIN, SOLEIMANIRAHBAR ATA, KARIMI GHARIB, DANESHVAR SIMIN, BASIRI ABBAS, RAZZAGHI ZAHRA, NAFAR MOHSEN, POUR REZA GHOLI FATEMEH, FARHANGI SOUDABEH
 
* LONDON HEALTH SCIENCES CENTRE, WESTERN UNIVERSITY, LONDON, ONTARIO, ST. JOSEPH’S HEALTH CARE, B3-420, 268 GROSVENOR STREET, LONDON, ONTARIO, N6A 4V2
 
Abstract: 

BACKGROUND: Different reports from Middle East countries demonstrated Kaposi’s sarcoma (KS) in transplant population. This vascular malignancy occurs mostly among immunocompromised individuals. Human herpesvirus 8 (HHV-8) appears to be the causative factor for the development of this neoplasm. Transplant programs are concerned about the frequencies of HHV-8 infection either in general population or transplant patients.
METHODS: The current study was conducted in two phases. Firstly, we detected antibodies against HHV-8 in 790 otherwise healthy blood donors. Secondly, a total of 125 kidney allograft recipients evaluated as being seropositive for HHV-8. We utilized enzyme immunoassay (EIA) for serologic studies.
RESULTS: Among blood donors, the male to female ratio was 1.05 (405 vs. 385) while the mean age was 38.9±11.7 years. The serostatus of none of these blood donors were positive for HHV-8. Among kidney recipients, the male to female ratio was 1.9 (82 vs. 43). The mean age was 39.01±14.77 years. Two (1.6%) patients were seropositive for HHV-8.
CONCLUSION: The prevalence of HHV-8 infection among Iranians is likely to be low. Yet, owing to the evidence of this infection among kidney allograft recipients and its probable role in developing post- transplantation KS (PT-KS), further studies appear to be required to keep the various aspects of this infection under close surveillance.

 
Keyword(s): HUMAN HERPESVIRUS 8, KIDNEY TRANSPLANTATION
 
References: 
  • ندارد
 
  pdf-File tarjomyar Yearly Visit 73
 
Latest on Blog
Enter SID Blog