Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   JUNE 2013 , Volume 16 , Number 6; Page(s) 348 To 350.
 
Paper: 

HEPATOCELLULAR CARCINOMA IN EXPLANTED LIVERS OF PATIENTS WITH GENOTYPE D HBV CIRRHOSIS: REPORT OF THE FIRST EXPERIENCE FROM IRAN

 
DOI: 

013166/AIM.008

 
Author(s):  GERAMIZADEH BITA*, NIKEGHBALIAN SAMAN, KAZEMI KUROSH, SHAMSAIFAR ALIREZA, BAHADOR ALI, SALAHI HESHMATOLLAH, MALEKHOSSEINI SEYED ALI, KESHTKAR JAHROMI MARZIEH, BAKHSHAI DEHKORDI ALI
 
* PATHOLOGY DEPARTMENT, TRANSPLANT RESEARCH CENTER, SHIRAZ UNIVERSITY OF MEDICAL SCIENCES, SHIRAZ, IRAN
 
Abstract: 

BACKGROUND: This study was conducted to determine the impact of hepatitis B virus (HBV) as a cause of hepatocellular carcinoma (HCC) in a single liver transplant center in Iran.
METHODS: We included all hepatectomy specimens from patients with HBV-related cirrhosis who underwent transplants from May 1993 until January 2012 in this study. From these, we determined the number that had HBV-induced HCC. Nested PCR results were used to determine the HBV genotype from sections of the hepatectomy pathology specimens.
RESULTS: During this time period there were 1361 cirrhotic livers transplanted in our center. Of these, 249 were attributed to HBV cirrhosis. Overall, HCC was detected in 40 (2.9%) subjects, of which 29 (1.2%) had HBV-related HCC. Genotype D was only genotype observed in all HBV subjects.
CONCLUSIONS: The results revealed that although HBV-related cirrhosis was the most frequent single cause for liver transplant, the frequency of HBV-induced HCC was very low among transplant recipients. Out of 1361 transplant recipients, only 29 (2.1%) were diagnosed with HBV-related HCC. All HBV subjects had genotype D.

 
Keyword(s): EXPLANTED LIVER, GENOTYPE D, HEPATOCELLULAR CARCINOMA
 
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