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Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   AUGUST 2013 , Volume 16 , Number 8; Page(s) 471 To 473.
 
Paper: 

VISCERAL LEISHMANIASIS-ASSOCIATED HEMOPHAGOCYTOSIS: A SINGLE CENTER EXPERIENCE

 
DOI: 

013168/AIm.007

 
Author(s):  MOKHTARI MARAL*, VIJAYANANDA KUMAR PERIKALA
 
* PATHOLOGY DEPARTMENT, SHIRAZ UNIVERSITY OF MEDICAL SCIENCES, ZAND ST., SHIRAZ, IRAN
 
Abstract: 

BACKGROUND: Kala-azar is a multisystem infection of the reticuloendothelial system. Various hematologic abnormalities have been described in kala-azar including hemophagocytic syndrome (HPS).
METHODS: We reviewed bone marrow aspirate smears from 18 documented cases of kala-azar complicated by HPS.
RESULTS: The bone marrow smears were hypercellular with erythroid hyperplasia. Megaloblastic changes, foamy macrophages, activated macrophages with cytoplasmic vacuoles and elongated cytoplasmic process, intra- and extracellular amastigotes, cytoplasmic fragments (blue bodies), plasma cells with inclusions and hemophagocytic cells were seen. Leishman bodies (amastigotes) were also found in some hemophagocytic cells.
CONCLUSION: Kala-azar should be considered as an etiology of HPS, particularly in endemic areas.

 
Keyword(s): BONE MARROW ASPIRATION FINDINGS, HEMOPHAGOCYTIC SYNDROME, KALA, AZAR
 
References: 
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