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Paper Information

Journal:   INTERNATIONAL JOURNAL OF ORGAN TRANSPLANTATION MEDICINE   2014 , Volume 5 , Number 1; Page(s) 7 To 14.
 
Paper: 

DIFFERENCES IN MEDICATION ADHERENCE BETWEEN LIVING AND DECEASED DONOR KIDNEY TRANSPLANT PATIENTS

 
 
Author(s):  DENHAERYNCK K., SCHMID MOHLER G., KISS A., STEIGER J., WUTHRICH R.P., BOCK A., DE GEEST S.*
 
* CENTER OF HEALTH SERVICES AND NURSING RESEARCH, K.U. LEUVEN, LEUVEN, BELGIUM RN, INSTITUTE OF NURSING SCIENCE, UNIVERSITY OF BASEL, BERNOULLISTRASSE 28, CH-4056 BASEL, SWITZERLAND
 
Abstract: 

Background: Literature review suggests that adherence to immunosuppressive drugs may be lower in recipients of living than of deceased donor kidney grafts, possibly because of profile differences.
Objective: To compare the level of immunosuppressive adherence levels between patients with deceased and living (-related;-unrelated) donor grafts in Switzerland.
Methods: Using data from two similar cross-sectional studies at two transplant centers in Switzerland, the level of adherence between the two groups was compared. Medication adherence was assessed by self-report or electronic monitoring. Possible explanatory factors included age, beliefs regarding immunosuppressive drugs, depressive symptomatology, pre-emptive transplantation, and the number of transplants received, were also considered. Data were analyzed using logistic regression analysis.
Results: Unadjusted non-adherence odds were 2 to 3 times higher in living-related than deceased donor transplantation (ORs: 2.09-3.05; p
<0.05). Adjustment for confounders showed that these differences were associated most with the younger age of living-related subjects and the belief that immunosuppressive drugs are less important for living-related donations.
Conclusion: There is a lower immunosuppressive adherence in recipients of living-related donor kidneys, possibly owing to differences in patient profile (ie, health beliefs regarding their immunosuppressive needs), knowledge of which may enhance adherence if addressed.

 
Keyword(s): LIVING RELATED TRANSPLANTATION, IMMUNOSUPPRESSANT ADHERENCE, KIDNEY TRANSPLANTATION, DONOR, GRAFT
 
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