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Paper Information

Journal:   INTERNATIONAL JOURNAL OF ORGAN TRANSPLANTATION MEDICINE   2014 , Volume 5 , Number 2; Page(s) 59 To 65.
 
Paper: 

MULTIVISCERAL AND SMALL BOWEL TRANSPLANTATION AT SHIRAZ ORGAN TRANSPLANT CENTER

 
 
Author(s):  NIKEGHBALIAN S.*, MEHDI S.H., ALIAKBARIAN M., KAZEMI K., SHAMSAEEFAR A., BAHREINI A., MANSOORIAN M.R., MALEKHOSSEINI S.A.
 
* SHIRAZ TRANSPLANT RESEARCH CENTER, SHIRAZ UNIVERSITY OF MEDICAL SCIENCES, SHIRAZ, IRAN
 
Abstract: 

Background: Multivisceral transplantations were initially done in animal models to understand the immunological effects. Later on, in human beings, it has been considered a salvage procedure for unresectable complex abdominal malignancies. With advancement in surgical techniques, availability of better immunosuppressive drugs, and development of better post-operative management protocols, outcomes have been improved after these complex surgical procedures.
Objective: To analyze and report results of multivisceral, modified multivisceral, and small bowel transplantations done at Shiraz Organ Transplant Center, Shiraz, southern Iran.
Methods: Medical records of all patients who underwent multivisceral, modified multivisceral, and small bowel transplants were retrospectively analyzed.
Results: There were 18 patients. The most common indications for the procedure in our series were unresectable carcinoma of pancreas followed by short bowel syndrome. 10 patients were alive after a median follow-up of 8.7 (range: 3–32) months. The remaining 8 patients died post-operatively, mostly from septicemia.
Conclusion: Multivisceral and small bowel transplantations are promising treatments for complex abdominal pathologies.

 
Keyword(s): MULTIVISCERAL, MODIFIED MULTIVISCERAL, SMALL BOWEL, TRANSPLANTATION, ANIMAL MODEL, ABDOMINAL MALIGNANCIES
 
References: 
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