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Paper Information

Journal:   IRANIAN ENDODONTIC JOURNAL (IEJ)   2013 , Volume 8 , Number 3; Page(s) 129 To 134.
 
Paper: 

THE PROPHYLACTIC EFFECTS OF ZINTOMA AND IBUPROFEN ON POST-ENDODONTIC PAIN OF MOLARS WITH IRREVERSIBLE PULPITIS: A RANDOMIZED CLINICAL TRIAL

 
 
Author(s):  RAMAZANI MOHSEN, HAMIDI MAHMOUD REZA, MOGHADDAMNIA ALI AKBAR, RAMAZANI NAHID*, ZARENEJAD NAFISEH
 
* DEPARTMENT OF PEDODONTICS, DENTAL SCHOOL, ZAHEDAN UNIVERSITY OF MEDICAL SCIENCES, ZAHEDAN, IRAN
 
Abstract: 

Introduction: Post endodontic pain is often linked to the inflammatory process as well as additional central mechanisms. The purpose of the present double-blind randomized clinical trial study was to compare the prophylactic effects of a derivative of Zingiber Officinale, Zintoma, and Ibuprofen on post endodontic pain of molars with irreversible pulpitis.
Materials and Methods: The post endodontic pain of 72 enrolled patients suffering from irreversible pulpitis was assessed after prophylactic use of 400 mg Ibuprofen, 2 gr Zintoma and placebo. Using the Heft-Parker Visual Analogue Scale, the patients recorded their perceived pain before taking the medicament (baseline), immediately after and also at 4, 8, 12, 24, 48, and 72 h post one-visit endodontic treatment. The statistical analysis was done using Kruskal-Wallis, Mann-Whitney, and Freedman tests (P<0.05).
Results: At all times, there was significant difference between the Ibuprofen and Zintoma (P<0.05) and also between the Ibuprofen and placebo (P<0.05). However, there was no significant difference between Zintoma and the placebo in any of time intervals (P>0.05). No side effects were observed.
Conclusion: The obtained results of the trial revealed that prophylactic use of 2 gr Zintoma is not an effective pain relieving agent.

 
Keyword(s): ANALGESICS, ANTI-INFLAMMATORY AGENTS, IBUPROFEN, NON-STEROIDAL, PAIN MEASUREMENT, PULPITIS, VISUAL ANALOGUE PAIN SCALE, ZINTOMA
 
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