Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   JUNE 2014 , Volume 17 , Number 6; Page(s) 411 To 416.
 
Paper: 

RECURRENCE RISK RATIO OF SIBLINGS AND FAMILIAL AGGREGATION OF THE METABOLIC SYNDROME AMONG TEHRANIAN POPULATION

 
DOI: 

014176/AIM.007

 
Author(s):  ZARKESH MARYAM, HOSSEINPANAH FARHAD, BARZIN MARYAM, HOSSEINZADEH NIMA, GUITY KAMRAN, DANESHPOUR MARYAM SADAT*, AZIZI FEREIDOUN
 
* CELLULAR AND MOLECULAR ENDOCRINE RESEARCH CENTER, RESEARCH INSTITUTE FOR ENDOCRINE SCIENCES SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

BACKGROUND: In this study, we aimed to determine the extent of possible genetic influence on cardio-metabolic risk factors, evaluate the familial aggregation of MetS and estimate the siblings’ recurrence risk ratios in a Tehrani population.
METHODS: In a cross-sectional observational study, we made anthropometric, blood pressure, and biochemical measurements in each member of 566 Tehrani nuclear families.
RESULTS: Grandmothers had the highest incidence of atherosclerotic risk factors. Four factors were found which accounted for 77.7% of the overall variance. Recurrence risk ratio among siblings was 5.61 (95% con?dence interval [CI]: 3.15–9.97). The adjusted odds ratio (OR) of proband’s MetS status was 1.33 (95% CI: 1.06–1.67). The adjusted OR for the four factors to predict MetS were all signi?cant, with obesity having the highest risk (OR: 7.50, CI: 5.91–9.52), followed by dyslipidemia/hyperglycemia (OR: 4.86, CI: 4.03–5.87), and blood pressure (OR: 4.20, CI: 3.51–5.02).
CONCLUSION: A high risk of MetS (five-fold) was found in siblings with MetS proband. Moreover, findings confirm the importance of obesity for the aggregation of MetS by nearly seven-fold in the study population.

 
Keyword(s): FAMILIAL AGGREGATION, METABOLIC SYNDROME, RECURRENCE RISK RATIO, TLGS
 
References: 
  • ندارد
 
  pdf-File tarjomyar Yearly Visit 74
 
Latest on Blog
Enter SID Blog