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Paper Information

Journal:   IRANIAN JOURNAL OF PEDIATRICS   JUN 2014 , Volume 24 , Number 3; Page(s) 267 To 272.
 
Paper: 

BLOOD EOSINOPHIL LEVELS IN NEWBORNS WITH SEVERE INDIRECT HYPERBILIRUBINEMIA TREATED WITH PHOTOTHERAPY

 
 
Author(s):  AYDIN BANU, BEKEN SERDAR*, ZENCIROGLU AYSEGUL, DILLI DILEK, OKUMUS NURULLAH
 
* DR. SAMI ULUS HASTANESI ANKARA, TURKEY
 
Abstract: 

Objective: Newborns who suffer from jaundice and/or receive phototherapy (PT) are at a higher risk of developing asthma. In this study we aimed to investigate the relationship between bilirubin and peripheral eosinophil counts in newborns with severe hyperbilirubinemia needing PT. Methods: In this study, a retrospective analysis was performed on 306 newborns with severe hyperbilirubinemia with gestational age³35 weeks (Group 1) and the control group consisted of 295 age and gender-matched newborns (Group 2). Total serum bilirubin, hemoglobin, albumin, leucocyte and eosinophil counts before and after PT were recorded from medical charts. Findings: All the patients in Group 1 received phototherapy and 77 (25.2%) of them needed exchange transfusion (ET). Before receiving PT, the patients in Group 1 had lower levels of Hb and higher levels of total serum bilirubin and lymphocytes than those in Group 2 although there was no statistically significant difference with regard to peripheral eosinophil counts. Eosinophils were detected to be numerically lower in Group 1. Higher bilirubin subgroups had also lower eosinophil counts. The patients in Group 1 had lower levels of Hb, leucocyte, albumin and higher levels of eosinophil following PT.
Conclusion: Peripheral eosinophil count may be affected by bilirubin levels and/or phototherapy. There is a need for further clinical research based on different models.

 
Keyword(s): NEWBORN, JAUNDICE, PHOTOTHERAPHY, EOSINOPHIL, ASTHMA
 
References: 
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