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Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   MAY 2013 , Volume 16 , Number 5; Page(s) 303 To 305.
 
Paper: 

CASE REPORT: DISSEMINATED CRYPTOCOCCOSIS WITH HEPATIC DYSFUCTION AS THE INITIAL MANIFESTATION IN AN IMMUNOCOMPETENT ADULT

 
 
Author(s):  ROHTAGI ANURAG*, AGGARWAL ANURADHA, CHABRA MUKESH KUMAR, DAHALE AMOL SONYABAPU
 
* 29/A SHAMNATH MARG CIVIL LINES, DELHI, INDIA
 
Abstract: 

Disseminated cryptococcosis is rare in immunocompetent hosts and hepatic manifestations as the presenting feature is further rare. We report a case of disseminated cryptococcosis with hepatic involvement as an initial manifestation in a previously healthy, immunocompetent adult. A young married female presented with progressive jaundice, anorexia, weightloss, cough with expectoration, and hepatosplenomegaly. Biochemical profile showed liver function derangement with increased transaminases, alkaline phosphatase, bilirubin with deranged coagulation assay, and decreased albumin. The patient was treated initially for disseminated tuberculosis with associated sepsis, but she succumbed on the third day. Diagnosis of cryptococcosis was made on the basis of sputum culture, serology, and liver histopathology.

 
Keyword(s): CRYPTOCOCCOSIS, HEPATIC, HIV, IMMUNOCOMPETENT
 
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