Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   IRANIAN JOURNAL OF PEDIATRICS   JUN 2014 , Volume 24 , Number 3; Page(s) 319 To 322.
 
Paper: 

ABSENCE OF ASSOCIATION BETWEEN -1131T>C POLYMORPHISM IN THE APOLIPOPROTEIN APOA5 GENE AND PEDIATRIC METABOLIC SYNDROME (SHORT COMMUNICATION)

 
 
Author(s):  FATEMI SAYEDEH GHAZALEH, EMADI BAYGI MODJTABA, NIKPOUR PARVANEH*, KELISHADI ROYA, HASHEMIPOUR MAHIN
 
* DEPARTMENT OF GENETICS AND MOLECULAR BIOLOGY, FACULTY OF MEDICINE, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, IRAN
 
Abstract: 

Objective: In the present study, we evaluated the association of rs662799 variant of the APOA5 gene with metabolic syndrome (MetS) in a sample of children and adolescents from Isfahan.
Methods: This case control study comprised 50 cases of MetS and 50 controls. Mismatched polymerase chain reaction–restriction fragment length polymorphism (mPCR-RFLP) was used to genotype-1131T>C polymorphism.
Findings: No significant association was documented for APOA5 genotypes with the measured laboratory parameters for CC, CT, and TT genotypes in the two groups studied. By logistic regression using a dominant model, the odds ratio (95% confidence interval0 for the MetS was 0.38 (0.139–1.0350 and 0.29 (0.08–1.071 for the unadjusted and adjusted models, respectively.
Conclusion: This study suggests that among studied children and adolescents,-1131T>C polymorphism in the APOA5 gene may not be a major contributor to the MetS risk..

 
Keyword(s): APOLIPOPROTEIN A5 GENE, METABOLIC SYNDROME, CHILDREN, ADOLESCENTS, TRIGLYCERIDE, CHOLESTEROL
 
References: 
  • ندارد
 
  pdf-File tarjomyar Yearly Visit 70
 
Latest on Blog
Enter SID Blog