Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   HEPATITIS MONTHLY   JUNE 2014 , Volume 14 , Number 6; Page(s) 0 To 0.
 
Paper: 

PORTAL HYPERTENSION AS IMMUNE MEDIATE DISEASE

 
 
Author(s):  MANTI SARA, MARSEGLIA LUCIA, ANGELO GABRIELLA D., FILIPPELLI MARTINA, CUPPARI CATERINA, GITTO ELOISA, ROMANO CLAUDIO, ARRIGO TERESA*, SALPIETRO CARMELO
 
* DEPARTMENT OF PEDIATRIC SCIENCES, GENETICS AND PEDIATRIC IMMUNOLOGY UNIT, UNIVERSITY OF MESSINA, MESSINA, ITALY
 
Abstract: 

Context: Portal Hypertension (PH) is a progressive complication due to chronic liver disease. In addition to pathophysiologic changes in the micro-circulation, in PH are established fibrous tissue (periportal fibrous septal) and regenerative hyperplastic nodules (from micro- to macro-nodules) promoting hepatic architectural distortion.
Evidence Acquisition: A literature search of electronic databases was undertaken for the major studies published from 1981 to today. The databases searched were: PubMed, EMBASE, Orphanet, Midline and Cochrane Library. We used the keywords: "portal hypertension, children, immune system, endocrine system, liver fibrosis".
Results: It is believed that PH results from three “phenotype”: ischemia-reperfusion, involving nervous system (NS); edema and oxidative damage, involving immune system; inflammation and angiogenesis, involving endocrine system. However, its exact cause still underdiagnosed and unknown.
Conclusions: PH is a dynamic and potentially reversible process. Researchers have tried to demonstrate mechanisms underlying PH and its related-complications. This review focuses on the current knowledge regarding the pathogenesis, and immune, endocrine-metabolic factors of disease. The strong positive association between immune system and development of PH could be efficient to identify non-invasive markers of disease, to modify prognosis of PH, and to development and application of specific and individual anti-inflammatory therapy.

 
Keyword(s): PORTAL HYPERTENSION, CHILDREN, IMMUNE SYSTEM, ENDOCRINE SYSTEM, LIVER FIBROSIS
 
References: 
  • ندارد
 
  pdf-File tarjomyar Yearly Visit 81
 
Latest on Blog
Enter SID Blog