SID.ir New Version

Use Online Translation Powered By

Click Here STRS

STRS

Paper Information
Journal:   HEPATITIS MONTHLY   MAY 2014 , Volume 14 , Number 5; Page(s) 0 To 0.
 
Paper: 

Granulocyte Colony Stimulating Factor Adjuvant Role On The Immunological Response To Hepatitis B Vaccine In Patients With Cirrhosis: A Double Blind Randomized Placebo Controlled Trial
 
 
Author(s):  Bagheri Lankarani Kamran, Talebzadeh Mozaffar, Eshraghian Ahad*, Malek Hosseini Seyed Ali
 
* DEPARTMENT OF INTERNAL MEDICINE, NAMAZI HOSPITAL, SHIRAZ UNIVERSITY OF MEDICAL SCIENCES, SHIRAZ, IR IRAN
 
Abstract: 
Background: Patients with liver cirrhosis have usually poor antibody response to hepatitis B virus (HBV) vaccination.Objectives: This study aimed to investigate the effect of granulocyte colony stimulating factor (G-CSF) on increasing antibody titers, after HBV vaccination, in patients with liver cirrhosis waiting for transplantation.Patients and Methods: From 56 patients with cirrhosis, 28 patients were allocated to receive double dose HBV vaccine (40 mgr) plus G-CSF and 28 patients were allocated to receive double dose HBV vaccine (40 mgr) plus placebo. Injections were performed on weeks 0, 4 and 8 and the blood samples were obtained one month after each vaccination session.Results: There was no statistically significant difference between anti-HBV antibody titers in patients receiving double dose HBV vaccination plus G-CSF and patients receiving double dose HBV vaccination plus placebo, after first, second or third vaccination rounds (P>0.05). Although the adjuvant G-CSF injection did not cause significant increased antibody titers in our patients compared to the placebo group, the increase in antibody titers following vaccination, happened faster in this group, compared to the placebo group.Conclusions: The present study showed that G-CSF is not superior to placebo in production of protective antibody titers after HBV vaccination but could result in a more rapid antibody response, compared to the placebo.
 
Keyword(s): HEPATITIS B, GRANULOCYTE COLONY-STIMULATING FACTOR, HBV VACCINE, LIVER CIRRHOSIS, CLINICAL TRIAL
 
 
International related papers: 
 
Most related Highly related Moderately related Least related
 
References: 
  • Not Registered.
  •  
  •  
 
Citations: 
  • Not Registered.
 
+ Click to Cite.
APA: Copy

BAGHERI LANKARANI, K., & TALEBZADEH, M., & ESHRAGHIAN, A., & MALEK HOSSEINI, S. (2014). GRANULOCYTE COLONY STIMULATING FACTOR ADJUVANT ROLE ON THE IMMUNOLOGICAL RESPONSE TO HEPATITIS B VACCINE IN PATIENTS WITH CIRRHOSIS: A DOUBLE BLIND RANDOMIZED PLACEBO CONTROLLED TRIAL. HEPATITIS MONTHLY, 14(5), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=410356



Vancouver: Copy

BAGHERI LANKARANI KAMRAN, TALEBZADEH MOZAFFAR, ESHRAGHIAN AHAD, MALEK HOSSEINI SEYED ALI. GRANULOCYTE COLONY STIMULATING FACTOR ADJUVANT ROLE ON THE IMMUNOLOGICAL RESPONSE TO HEPATITIS B VACCINE IN PATIENTS WITH CIRRHOSIS: A DOUBLE BLIND RANDOMIZED PLACEBO CONTROLLED TRIAL. HEPATITIS MONTHLY. 2014 [cited 2022May21];14(5):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=410356



IEEE: Copy

BAGHERI LANKARANI, K., TALEBZADEH, M., ESHRAGHIAN, A., MALEK HOSSEINI, S., 2014. GRANULOCYTE COLONY STIMULATING FACTOR ADJUVANT ROLE ON THE IMMUNOLOGICAL RESPONSE TO HEPATITIS B VACCINE IN PATIENTS WITH CIRRHOSIS: A DOUBLE BLIND RANDOMIZED PLACEBO CONTROLLED TRIAL. HEPATITIS MONTHLY, [online] 14(5), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=410356.
 
  pdf-File
Yearly Visit 57
 
 
Latest on Blog
Enter SID Blog