The first case of multi-drug resistant (MDR) tuberculosis (TB) was reported in 1993 in New York City and the next year the World Health Organization (WHO) declared a global TB emergency (1, 2). Two decades later, in 2010, WHO estimated that 650,000 cases of MDR TB have been reported worldwide (3). This was not the end of the explosive process, and estimation of WHO for 2015 was more than 1.3 million people in 27 countries (2). Unfortunately, the world confronted more complications during the 2000s. Reports of extensively drug-resistant TB (XDR) and totally drug-resistant TB (TDR) were published between 2003 and 2006 (2, 4).