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Paper Information

Journal:   IRANIAN JOURNAL OF PUBLIC HEALTH   OCTOBER 2014 , Volume 43 , Number 10; Page(s) 1417 To 1423.
 
Paper: 

EFFECT OF VITAMIN E AND METFORMIN ON FATTY LIVER DISEASE IN OBESE CHILDREN- RANDOMIZED CLINICAL TRIAL

 
 
Author(s):  SHIASI ARANI KOBRA, TAGHAVI ARDAKANI ABBAS, MOAZAMI GOUDARZI RAZIEH*, TALARI HAMID REZA, ADHAMI KAMRAN, HAMI KAMRAN, AKBARI HOSSEIN, AKBARI NIMA
 
* DEPT. OF PEDIATRICS, KASHAN UNIVERSITY OF MEDICAL SCIENCES, KASHAN, IRAN
 
Abstract: 

Background: We evaluated the effect of vitamin E and metformin on fatty liver disease in obese children.
Methods: This interventional study has been done on 119 children with Non-alcoholic fatty liver disease (based on sonography results). Patients were divided into four treatment groups; they received metformin 1gr daily (age<12 years), metformin 1.5 gr daily (age>12 years), vitamin E 800 U daily and vitamin E 400 U daily. Liver sonography was performed for patients for two periods of two months. This trial was registered in Iranian Registry of Clinical Trials (IRCT), No.IRCT2013021012421N1 Results: The study group comprised 119 individuals (62 females, 57 males). The mean age was 10 ± 3.19 yr. There was no significant difference in terms of sex and BMI between the groups. Overall liver sonography showed normal liver in 66 patients (55.46%), 66.63% after two months and 33.37% after four months. After two months, the most therapeutic response observed in the group which received vitamin E 800 u daily (48.1%) and the least therapeutic response was in the group which received vitamin E 400 u daily (14.3%). After four months, the greater response was seen in vitamin E 400 u daily group (45.8%) and the least response in the metformin 1 gram daily group (19%).
Conclusion: In comparison with metformin, vitamin E is more influential in remission; however both are efficient in treatment of fatty liver. Vitamin E 400 u daily responses better in four-month treatment.

 
Keyword(s): FATTY LIVER DISEASE, OBESITY, CHILDREN, METFORMIN, VITAMIN E
 
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