Paper Information

Journal:   IRANIAN JOURNAL OF PUBLIC HEALTH   OCTOBER 2014 , Volume 43 , Number 10; Page(s) 1405 To 1416.
 
Paper: 

THE EFFECT OF MELATONIN ON CLIMACTERIC SYMPTOMS IN MENOPAUSAL WOMEN; A DOUBLE-BLIND, RANDOMIZED CONTROLLED, CLINICAL TRIAL

 
 
Author(s):  PARANDAVAR NEHLEH, ABDALI KHADIJEH*, KESHTGAR SARA, EMAMGHOREISHI MAASOUMEH, AMOOEE SEDDEGHEH
 
* DEPT. OF MIDWIFERY, SCHOOL OF MIDWIFERY, SHIRAZ UNIVERSITY OF MEDICAL SCIENCES, SHIRAZ, IRAN
 
Abstract: 

Background: Menopause is one of the most critical periods of woman's life.With reducing of ovarian estrogen; women are more prone to psychological and physical symptoms.
The present study aimed to investigate the effect of melatonin on the climacteric symptoms.
Methods: The present double blind, placebo randomized controlled clinical trial was conducted on 240 menopausal women (40 - 60 years old) referring to the gynecology clinics of Shiraz University of Medical Sciences (January - November 2012).
The participants were randomly divided into two groups through sortition. Demographic characteristics, Goldberg’s general health questionnaire (GHQ), Greene Climacteric Scale and level of Follicle Stimulating Hormone (FSH) were determined for both groups before the intervention. The intervention group received one 3mg melatonin tablet each night for 3 months and the control group received the placebo in the same period.
Changes of climacteric symptoms and drug complications were measured 1, 2 and 3 months after the intervention Results: We analyzed the data of 99 postmenopausal women in the intervention group and 101 postmenopausal women in the control group. In the melatonin group, the climacteric symptoms score decreased from 35.73+11.6 to 17.09+10.22 during the 3-month study period and regardless of time, a significant difference was observed between the two groups (P<0.001). In addition, a significant difference was found between the two groups regarding various dimensions of the climacteric symptoms over time (P<0.001). No significant difference was found regarding side effects between the two groups (P=0.135).
Conclusion: The study findings showed that using melatonin improved the climacteric symptoms.

 
Keyword(s): CLIMACTERIC SYMPTOMS, GREEN SCALE, MELATONIN, MENOPAUSAL WOMEN, RCT
 
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