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Journal:   ARCHIVES OF PEDIATRIC INFECTIOUS DISEASES   JANUARY 2015 , Volume 3 , Number 1; Page(s) 1 To 4.
 
Paper: 

Susceptibility Pattern Of Bacille Calmette-Guerin Strains Against Pyrazinamide And Other Major Anti-Mycobacterial Drugs

 
 
Author(s):  Fahimzad Seyed Alireza, Ghasemi Mahmood, Shiva Farideh, Ghadiri Keyghobad, Navidinia Masoumeh, Karimi Abdollah*
 
* PEDIATRIC INFECTIONS RESEARCH CENTER, MOFID CHILDREN’S HOSPITAL, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IR IRAN
 
Abstract: 
Background: BCG (Bacille Calmette-Guerin) vaccine is an attenuated live vaccine administered to prevent Tuberculosis. Disseminated infection due to BCG is a rare life threatening complication of this vaccine, especially in immunocompromised patients. Objectives: The current study evaluated the sensitivity pattern of the BCG strain supplied by the Institute de Pasteur, Iran against antimycobacterial drugs used to treat disseminated infection caused by the vaccine.Patients and Materials: Bacille Calmette-Guerin strain ATCC 1173 P was purchased from the Pasteur Institute in Tehran and three samples of Mycobacterium bovis isolated from subaxillary adenitis of three patients were tested for susceptibility to major anti-mycobacterial drugs by MODS (microscopic observation drug sensitivity) method.Results: All samples of BCG strain were resistant to most of the anti-mycobacterial drugs used separately except for concentrations of isoniazid 1 mg/mL, ethambutol 3 mg/mL, ciprofloxacin 4 mg/mL and clarithromycin 2 mg/mL. Addition of pyrazinamide (PZA) 25 mg/mL, the susceptibility pattern did not change to any drug, but increasing PZA concentration to 50 mg/ml and combining it with ethionamide 2 mg/mL, isoniazid 0.2 mg/mL, streptomycin 2 mg/mL, rifampin 0.5 mg/mL or ciprofloxacin 0.2 mg/mL, made the Mycobacterium strains susceptible.Conclusions: The current study findings revealed that Mycobacterium bovis resistance to pyrazinamide is resolved by increasing the concentration of the drug and combining PZA with other anti-mycobacterial agents.
 
Keyword(s): MYCOBACTERIUM BOVIS, PYRAZINAMIDE, RESISTANCE
 
 
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APA: Copy

FAHIMZAD, S., & GHASEMI, M., & SHIVA, F., & GHADIRI, K., & NAVIDINIA, M., & KARIMI, A. (2015). SUSCEPTIBILITY PATTERN OF BACILLE CALMETTE-GUERIN STRAINS AGAINST PYRAZINAMIDE AND OTHER MAJOR ANTI-MYCOBACTERIAL DRUGS. ARCHIVES OF PEDIATRIC INFECTIOUS DISEASES, 3(1), 1-4. https://www.sid.ir/en/journal/ViewPaper.aspx?id=410252



Vancouver: Copy

FAHIMZAD SEYED ALIREZA, GHASEMI MAHMOOD, SHIVA FARIDEH, GHADIRI KEYGHOBAD, NAVIDINIA MASOUMEH, KARIMI ABDOLLAH. SUSCEPTIBILITY PATTERN OF BACILLE CALMETTE-GUERIN STRAINS AGAINST PYRAZINAMIDE AND OTHER MAJOR ANTI-MYCOBACTERIAL DRUGS. ARCHIVES OF PEDIATRIC INFECTIOUS DISEASES. 2015 [cited 2022June30];3(1):1-4. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=410252



IEEE: Copy

FAHIMZAD, S., GHASEMI, M., SHIVA, F., GHADIRI, K., NAVIDINIA, M., KARIMI, A., 2015. SUSCEPTIBILITY PATTERN OF BACILLE CALMETTE-GUERIN STRAINS AGAINST PYRAZINAMIDE AND OTHER MAJOR ANTI-MYCOBACTERIAL DRUGS. ARCHIVES OF PEDIATRIC INFECTIOUS DISEASES, [online] 3(1), pp.1-4. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=410252.



 
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