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Paper Information

Journal:   ACTA MEDICA IRANICA   2014 , Volume 52 , Number 8; Page(s) 0 To 0.
 
Paper: 

THE PIGEONHOLE OF OCCULT HEPATITIS B (REVIEW ARTICLE)

 
 
Author(s):  DINDOOST PAYAM, CHIMEH NARGES, HOLLINGER BLAIN F., SABERFAR ESMAEIL, NOROUZI MEHDI, JAZAYERI SEYED MOHAMMAD*
 
* DEPARTMENT OF VIROLOGY, FACULTY OF PUBLIC HEALTH, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Occult Hepatitis B (OHB), or persistent hepatitis B virus (HBV) viremia in surface-antigen-HBsAg-negative patients, has been recognized as a medical concern during the last decade. The exact magnitude, pathogenesis and clinical relevance of OHB are unclear. This review organizes the published data on OHB and presents an overview of the current hypotheses on OHB’s pathogenesis and clinical relevance. Many explanations have been offered for the pathogenesis of OHB, ranging from the inability of standard immunoassays to diagnose OHB to the involvement of the versatile virus-host factors Also, special care should be taken regarding the diagnosis of OBH. It seems that both shared viral-host factors are involved in the pathogenesis of OBH. Further molecular studies on cohort patients group need to explore such association.

 
Keyword(s): OCCULT HEPATITIS B INFECTION, HBV DIAGNOSIS, HBSAG MUTATIONS
 
References: 
 
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