Paper Information

Journal:   MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD)   JULY 2014 , Volume 6 , Number 3; Page(s) 151 To 155.
 
Paper: 

CLINICAL AND PATHOLOGICAL FEATURES OF NON-FUNCTIONAL NEUROENDOCRINE TUMORS OF PANCREAS: A REPORT FROM IRAN

 
 
Author(s):  NOZARI NEDA, NIKFAM SEPIDEH, NIKMANESH ARASH, MOHAMADNEJAD MEHDI, SOTOUDEHMANESH RASOUL, ZAMANI FARHAD, MERAT SHAHIN, MALEKZADEH REZA, POURSHAMS AKRAM*
 
* DIGESTIVE DISEASE RESEARCH INSTITUTE, SHARIATI HOSPITAL, N KARGAR ST. TEHRAN14117, IRAN
 
Abstract: 

BACKGROUND: Pancreatic neuroendocrine tumors (PNETs) are rare tumors with variable malignant potential, prognosis, and survival. We aimed to assess the characteristics of patients with non- functional PNET in our hospital.
METHODS from Nov 2010 to Nov 2013, all patients who came to endosonography unit of Shariati hospital, Tehran, Iran, and had pancreatic lesions were assessed. Tumor samples were obtained through fine needle aspiration. Various characteristics of the non- functional PNET were recorded and patients were followed up to three years.
RESULTS: Twenty eight non func-PNET cases, aged 37-72 years were identified, 15 (53.6%) of whom were men. Fifteen (53.6%) tumors were located in the head and 5 (17.8%) in the body of the pancreas. The mean tumor size was 3.9 Cm and 10.7%, 28.6%, 32.1%, and 28.6% of the patients were at stages I, II, III and IV, respectively. Of the patients, 12 (43%) underwent surgery, 3 (10.7%) received chemotherapy, and 13 (46.4%) received no treatment. During the mean follow-up of 16 months, the disease had progressed in 3 (10.7%) patients and 10 (35.7%) had died. In univariate analysis, tumor size>3Cm and Ki-67>20% were correlated with survival rate but not in multivariate analysis.
CONCLUSION: Iranian patients with non- functional PNET present similar characteristics to world patients. There is a need to establish efficacy of tumor samples which are obtaining through fine needle aspiration for assessing tumor grading.

 
Keyword(s): NEUROENDOCRINE TUMORS, EPIDEMIOLOGY, SURVIVAL
 
References: 
  • ندارد
 
  pdf-File tarjomyar Yearly Visit 77
 
Latest on Blog
Enter SID Blog