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Paper Information

Journal:   IRANIAN JOURNAL OF PUBLIC HEALTH   AUGUST 2014 , Volume 43 , Number SUPPLEMENT 2; Page(s) 42 To 42.
 
Paper: 

PREVALENCE OF ESBL AND MBL IN ACINETOBACTER BAUMANII ISOLATED FROM IRANIAN PATIENTS DURING THE RECENT 10 YEARS

 
 
Author(s):  HASANVAND BANAFSHE*, KASHEF MAHSA, ALVANDI AMIRHOOSHANG, ABIRI RAMIN
 
* MICROBIOLOGY DEPARTMENT, FACULTY OF MEDICINE, KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES, KERMANSHAH, IRAN
 
Abstract: 

Background: Beta-lactam resistance appears to be primarily caused by b-lactamase production, including the extended spectrum b-lactamases, AmpC beta-lactamases, metallo-b- lactamases and oxacillinases. They are mostly consisting of KPC, VIM, IMP, NDM, and OXA-48 types. The aim of this study was to review the data about prevalence of ESBL and MBL in A. baumanii isolated from Iranian patients that were published during the recent 10 years.
Methods: The scientific search and data collection were done by two researchers. Acinetobacter, MBL, ESBL and antibiotic resistance in Persian and English were used as keywords. Scientific database including Google scholar, PubMed, and all medical scientific journals and also abstracts of the Microbiology Congress were searched. All articles related to detection of MBL and ESBL using phenotypic methods (Etest, Double Disk Synergy Test, Combined Disk, Hodge test) and genotypic (PCR) were collected. The data including the method of detection, number of isolates, number of ESBL and MBL and their genotypes and …, were extracted.
Results: Among 48 selected articles, 20 articles were met the inclusion criteria finally. In total 1857 isolates have been subjected to ESBL and MBL phenotypic and genotypic analysis in different cities. The prevalence of ESBL among 694 isolates that were analyzed for that was 42.2% (293/694). The prevalence of MBL among 366 samples that were tested for that was 68.6% (251/366). The most common genotypes for MBL and ESBL were IMP-1 (2.06%) and PER-1) 47.5%) respectively. Detail of prevalence of MBL and ESBL genotype will be shown in a table in poster.
Conclusion: In order to monitor and control the spread of horizontal transfer of resistance; genotyping studies are essential.

 
Keyword(s): ACINETOBACTER, MBL, ESBL, ANTIBIOTIC RESISTANCE
 
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