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Journal:   ARCHIVES OF PEDIATRIC INFECTIOUS DISEASES   JULY 2014 , Volume 2 , Number 3; Page(s) 1 To 5.
 
Paper: 

High Prevalence Of Metallo-Beta-Lactamase Producing Acinetobacter Baumannii Isolated From Two Hospitals Of Tehran, Iran

 
 
Author(s):  Noori Maryam, Karimi Abdollah, Fallah Fatemeh, Hashemi Ali*, Alimehr Shadi, Goudarzi Hossein, Aghamohammad Shadi
 
* DEPARTMENT OF MICROBIOLOGY, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IR IRAN
 
Abstract: 
Background: Metallo-beta-lactamase (MBL)-producing Acinetobacter baumannii is a growing therapeutic concern, worldwide.Objectives: The aim of this study was to determine the frequency of SPM and IMP type genes among A. baumannii isolates from hospitalized patients in Loghman Hakim and Milad hospitals, Tehran-Iran from 2012 to 2013.Patients and Methods: This study was conducted on 108 A. baumannii isolates collected from two hospitals in Tehran, Iran. Antibiotic susceptibility tests were performed by Kirby-Bauer disc diffusion and Broth microdilution methods according to clinical laboratory standards institute (CLSI) guidelines, and combined disk diffusion test (CDDT) was performed for identification of metallo-beta-lactamases (MBLs). The blaIMP and blaSPM genes were detected by PCR and sequencing methods.Results: The resistance of A. baumannii isolates against tested antibiotics were as follow: 108 (100%) to cefotaxime, 103 (95.4%) to ceftazidime, 99 (91.7%) to meropenem, 99 (91.7%) to imipenem, 44 (40.7%) to gentamicin, 87 (80.6%) to amikacin, 100 (92.6%) to ciprofloxacin, 105 (95.7%) to cefepime, 105 (97.2%) to piperacillin, 103 (95.4%) to piperacillin/tazobactam, 106 (98.1%) to ampicillin/ sulbactam, 106 (98.1%) to co-trimoxazole, 87 (80.6%) to tetracycline and 1 (1.8%) to colistin. Using combined disk diffusion test, it was found that out of 99 imipenem non-susceptible A. baumannii strains, 86 (86.86%) were MBL producers. The prevalence of IMP-1 gene among metallo-beta-lactamase-producing A. baumannii isolates was 3 of 86 (3.48%).Conclusions: The prevalence of metallo-beta-lactamase-producing A. baumannii strains detected in this study is of great concern and highlights the need of infection control measures including antibacterial management and prompt identification of betalactamase-producing isolates.
 
Keyword(s): ACINETOBACTER BAUMANNII, DRUG RESISTANCE, BLAIMP-1
 
 
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APA: Copy

NOORI, M., & KARIMI, A., & FALLAH, F., & HASHEMI, A., & ALIMEHR, S., & GOUDARZI, H., & AGHAMOHAMMAD, S. (2014). HIGH PREVALENCE OF METALLO-BETA-LACTAMASE PRODUCING ACINETOBACTER BAUMANNII ISOLATED FROM TWO HOSPITALS OF TEHRAN, IRAN. ARCHIVES OF PEDIATRIC INFECTIOUS DISEASES, 2(3), 1-5. https://www.sid.ir/en/journal/ViewPaper.aspx?id=410098



Vancouver: Copy

NOORI MARYAM, KARIMI ABDOLLAH, FALLAH FATEMEH, HASHEMI ALI, ALIMEHR SHADI, GOUDARZI HOSSEIN, AGHAMOHAMMAD SHADI. HIGH PREVALENCE OF METALLO-BETA-LACTAMASE PRODUCING ACINETOBACTER BAUMANNII ISOLATED FROM TWO HOSPITALS OF TEHRAN, IRAN. ARCHIVES OF PEDIATRIC INFECTIOUS DISEASES. 2014 [cited 2022June30];2(3):1-5. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=410098



IEEE: Copy

NOORI, M., KARIMI, A., FALLAH, F., HASHEMI, A., ALIMEHR, S., GOUDARZI, H., AGHAMOHAMMAD, S., 2014. HIGH PREVALENCE OF METALLO-BETA-LACTAMASE PRODUCING ACINETOBACTER BAUMANNII ISOLATED FROM TWO HOSPITALS OF TEHRAN, IRAN. ARCHIVES OF PEDIATRIC INFECTIOUS DISEASES, [online] 2(3), pp.1-5. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=410098.



 
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