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Paper Information

Journal:   HEPATITIS MONTHLY   AUGUST 2014 , Volume 14 , Number 8; Page(s) 0 To 0.
 
Paper: 

HLA-DPB1 VARIANT EFFECT ON HEPATITIS B VIRUS CLEARANCE AND LIVER CIRRHOSIS DEVELOPMENT AMONG SOUTHWEST CHINESE POPULATION

 
 
Author(s):  HU ZHANGYONG*, YANG JUN, XIONG GUOLIAN, SHI HAN, YUAN YUAN, FAN LIN, WANG YALI
 
* DEPARTMENT OF INFECTION DISEASES, FIRST AFFILIATED HOSPITAL, CHENGDU MEDICAL COLLEGE, CHENGDU, CHINA
 
Abstract: 

Background: Previous studies have shown that genetic variants in HLA-DP genes affect disease progression in hepatitis B virus (HBV) infection.
Objectives: We aimed to evaluate possible association between HLA-DPB1 rs9277534 polymorphism and different clinical complications of hepatitis B virus (HBV) infection.
Materials and Methods: Snapshot assay was used to investigate the association of rs9277534 polymorphism in 342 patients with persistent HBV infection and 342 age and gender-matched HBV spontaneous clearance controls. Patients were categorized into asymptomatic HBV carriers (AsC, n
=104), chronic hepatitis B (CHB, n=116), and liver cirrhosis (LC, n=122) subgroups.
Results: There was a significantly higher proportion of the rs9277534 minor allele A in HBV spontaneous clearance control than that in HBV persistent infection group (OR
=0.58, 95%CI=0.46-0.73, P<0.0001). Genotypic analysis showed that GA and AA genotypes were associated with HBV spontaneous clearance (GA: OR=0.56, 95%CI=0.40-0.79, P=0.019; AA: OR=0.24, 95%CI=0.14-0.44, P<0.0001). A significant difference was found between AsC and LC groups in the distribution of AA genotype (OR=9.32, 95%CI=1.293-67.14, P=0.027).
Conclusions: Variant at rs9277534 could affect both the spontaneous clearance of HBV infection and progression from asymptomatic HBV carriers to HBV-related liver cirrhosis in Southwest Han Chinese population.

 
Keyword(s): HEPATITIS B VIRUS, SINGLE NUCLEOTIDE POLYMORPHISM, HUMAN, LEUKOCYTE, ANTIGEN
 
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