Background: Rapid multi drug resistant property of A.baumannii has become a great concern in clinical fields. Due to its resistance to almost all the commercial antibiotic classes in hospitals, searching for a new material has become an important matter. Hence, in this study the antibacterial effect of methanolic extract of Zingiber offinale and Crucuma lonaga has been evaluated against drug resistant A. baumannii isolates from burn infection.
Methods: 30 drug resistant A.baumannii strains, which were isolated from burn wounds at Motahari hospital of Tehran within 2013, were selected. The plants were purchased from a famous Atari of Tehran and the methanolic extracts of them were prepared by percolator apparatus. Antibacterial activity of the methanolic extract was evaluated by disc diffusion method based on CLSI protocol.
Results: The mean of diameter of the inhibition zone for different concentrations of extracts were; 12.30±6.03 mm at the 400 ppm, 11.47±5.40 mm at the 200 ppm, 11.17±5.03 mm at the 100 ppm, 10.52±4.70 mm at the 50 ppm and 10.46±4.02 mm at the concentration of 25 ppm.
Conclusion: Clinical strains of A. baumannii were almost highly resistant to imipenem which is the common choice of antibiotic therapy in the hospitals. This result can show the synergism of antibacterial property of the methanolic extract of C. longa and Z. officinale. Furtherin vivo studies are recommended.