Paper Information

Journal:   HEPATITIS MONTHLY   SEPTEMBER 2014 , Volume 14 , Number 9; Page(s) 0 To 0.
 
Paper: 

DIAGNOSTIC VALUE OF SERUM LEVEL OF SOLUBLE TUMOR NECROSIS FACTOR RECEPTOR II? IN EGYPTIAN PATIENTS WITH CHRONIC HEPATITIS C VIRUS INFECTION AND HEPATOCELLULAR CARCINOMA

 
 
Author(s):  SHAWKY A. FOUAD*, ELSAAID NEHAL H., MOHAMED NAGWA A., ABUTALEB OSAMA M.
 
* DEPARTMENT OF INTERNAL MEDICINE, FACULTY OF MEDICINE, CAIRO UNIVERSITY, CAIRO, EGYPT
 
Abstract: 

Objectives: The aim of this study was to determine the value of serum soluble tumor necrosis factor (TNF) receptor-II? (sTNFR-II?) in diagnosis of HCC in patients with chronic hepatitis C virus (HCV) infection.
Patients and Methods: The study was performed on 110 subjects who were classified into five groups. Group I included 20 patients with chronic noncirrhotic HCV infection and persistently normal transaminases for³6 months. Group II included 20 patients with chronic noncirrhotic HCV infection and elevated transaminases. Group III included 20 patients with Chronic HCV infection and liver cirrhosis. Group IV included 20 patients with chronic HCV infection with liver cirrhosis and HCC. Group V included 30 healthy age and sex-matched controls. Medical history was taken from all participants and they underwent clinical examination and abdominal ultrasonography. In addition, the following laboratory tests were requested: liver function tests, complete blood count, HBsAg, anti-HCVAb, HCV-RNA by qualitative PCR, and serum levels of ?-fetoprotein (AFP) and sTNFR-II?.
Results: The serum level of sTNFR-II? was significantly higher in patients with HCC in comparison to the other groups. A positive correlation was found between the serum levels of sTNFR-II? and AST and ALT in patients of group-II. Diagnosis of HCC among patients with HCV infection and cirrhosis could be ascertained when sTNFR-II? is assessed at a cutoff value of
³250 pg/mL.
Conclusions: Serum sTNFR-II? could be used as a potential serum marker in diagnosing HCC among patients with HCV infection.

 
Keyword(s): LIVER CIRRHOSIS, HEPATOCELLULAR CARCINOMA, HEPATITIS C VIRUS, S TNF-RII
 
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