Paper Information

Journal:   IRANIAN JOURNAL OF PUBLIC HEALTH   AUGUST 2014 , Volume 43 , Number SUPPLEMENT 2; Page(s) 35 To 35.
 
Paper: 

ACINETOBACTER BAUMANII AND NONBAUMANII IN IRAN, EVALUATION OF ANTIBIOTIC RESISTANCE

 
 
Author(s):  ABBASI FARHAD*, KHALILI AZAD MANSOOREH, ASADI SOROUR, YADEGARYNIA DAVOOD, GHOLAMIN SHARAREH, GACHKAR LATIF
 
* BUSHEHR UNIVERSITY OF MEDICAL SCIENCES
 
Abstract: 

Background: Acinetobacter species have become increasingly resistant to antibiotics over the past several years and these days there is a significant challenge in treating these infections. They are important causes of nosocomial infections.
Methods: In a prospective study, we evaluated 100 positive cultures of Acinetobacter from 100 patients in different wards of seven tertiary care hospitals in Tehran, Iran. PCR was used to determine the species of Acinetobacter E-test and Disk diffusion method were used to determine the resistance of isolated Acinetobacter baumannii and non- baumannii. Antimicrobial sensitivity to ceftazidime, cefepime, amikacin, imipenem, piperacillin-tazobactam, tigecycline and colistin was analyzed.
Results: In our study 89% of the isolated Acinetobacter was baumannii and 11% was non- baumannii. 70% of samples were isolated from male and 30% of the isolates from female patients. The most incriminated wards were intensive care and burn units. Acinetobacter was isolated from respiratory secretion in 38%, wound in 29%, tip of catheter in 14%, urine in 8%, blood in 4%, CSF in 4%, pleural fluid in 2% and brain abscess in 1% of samples. Acinetobacter was resistant to amikacin and ceftazidime in 100%, to cefepime in 94.5%, to piperacillin- tazobactam in 83% and to imipenem in 64% of all samples. Sensitivity to colistin was 100% and to tigecycline was 74.5% in our study. Conclusion: Acinetobacter is an increasingly isolated pathogen. The prevalence of cephalosporins and carbapenem resistant Acinetobacter is high in our study. Colistin and tigecycline are the best choices for treatment of Acinetobacter.

 
Keyword(s): ACINETOBACTER, ANTIBIOTICS, RESISTANT
 
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