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Paper Information

Journal:   IRANIAN JOURNAL OF PUBLIC HEALTH   AUGUST 2014 , Volume 43 , Number SUPPLEMENT 2; Page(s) 33 To 33.
 
Paper: 

FREQUENCY OF ADHESIVE VIRULENCE FACTORS IN CARBAPENEMASE-PRODUCING ACINETOBACTER BAUMANNII ISOLATED FROM CLINICAL SAMPLES IN WEST OF IRAN

 
 
Author(s):  MOHAJERI PARVIZ*, REZAEI ZHALEH, FARAHANI ABBAS, SHARBATI SABA
 
* DEPARTMENT OF MICROBIOLOGY, SCHOOL OF MEDICINE, KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES, KERMANSHAH, IRAN
 
Abstract: 

Background: Acinetobacter baumannii is a significant opportunistic pathogen which causes severe infections related to catheters and ventilator. Adhesive virulence factors (VFs) are effective in A. baumannii adherence and pathogenicity. The aim of this study is to evaluate the frequency of adhesive virulence factors in carbapenemase-producing A.baumannii.
Methods: In total, 104 A. baumannii were collected from teaching hospitals of Kermanshah, Iran within March 2011 to March 2013. All the isolates were tested for antimicrobial susceptibility by Kirby-Bauer disk diffusion method. Carbapenemase- producing isolates were identified, DNA of isolates was extracted by boiling and it was investigated for the presence of adhesive virulence factors by PCR.
Results: Among 50 carbapenemase-producing isolates, the frequency of fimH and csgA genes was found to be 30 (60%) and 27 (54%), respectively. 20 isolates (40%) carried both of fimH and csgA genes, but 13 (26%) carried none of these two genes. None of these isolates presented genes codifying for other different adhesive virulence factors include fimbriae Dr (afa/draBC), fimbriae S (sfa/focDE), fimbriae P (pap), capsule (kpsMT), fibronecting receptor (fnb).
Conclusion: Adhesive virulence factors are responsible for pathogenesis of bacteria. As adhesive VFs, fimbriae type I (fimH) and curli fiber (csgA) are participated in adherence and biofilm formation. These factors give bacteria the ability to be hidden from the host immune system, then they cauese infections. More than 50% prevalence of fimH and csgA genes among 7 adhesive VFs studied in this research show that maybe there is a significant relationship between the presence of fimH and csgA genes and A. baumannii infections.

 
Keyword(s): ACINETOBACTER BAUMANNII, VIRULENCE FACTORS, CARBAPENEMASE- PRODUCING, ADHESIVE
 
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