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Paper Information

Journal:   IRANIAN JOURNAL OF PUBLIC HEALTH   AUGUST 2014 , Volume 43 , Number SUPPLEMENT 2; Page(s) 33 To 33.
 
Paper: 

MLVA TYPING OF ACINETOBACTER BAUMANNII AS A MULTIDRUG-RESISTANT ORGANISM, ISOLATED FROM TEHRAN HOSPITALS

 
 
Author(s):  KARMOSTAJI AFSANEH*, NAJAR PEERAYEH SHAHIN
 
* INFECTIOUS AND TROPICAL DISEASES RESEARCH CENTER, HORMOZGAN UNIVERSITY OF MEDICAL SCIENCES, BANDAR ABBAS, IRAN
 
Abstract: 

Background: Acinetobacter baumannii has emerged as an important nosocomial pathogen, with ability to acquire antibiotic resistance genes. The aim of this study was to characterize the resistance mechanisms and genetic relatedness of MDR Acinetobacter baumannii isolates collected in Tehran hospitals.
Methods: The resistance phenotypes and genomic diversity of 123 Acinetobacter baumannii isolates obtained from 2 hospitals in Tehran from 2009 to2010 were determined using antimicrobial susceptibility testing and multilocus variable number tandem repeat (MLVA).
Results: Antibiogram analyses showed that the isolates were fully resistant to b-lactam antimicrobials and had high resistance rates to the other antimicrobial agents tested. 30 isolates (24.4%) were found to be MDR isolates. All MDR A. baumannii isolates were resistant to imipenem (MIC
³16 mg/L) and 29 (96.7%) of them were resistant to Meropenem. 28 isolates (93.3%) were positive for bla OXA-23-like, two were positive for bla OXA-24-like. All isolates possesed ISAba1in the upstream region of the OXA-23-like gene. MLVA typing of MDR isolates showed 7 clonal complexes and 16 singelton.
Conclusion: The population structure of A. baumannii isolates is diverse. Isolates possess seven resistance gene determinants that give rise to the MDR phenotype. These data provide a better understanding of A. baumannii epidemiology within the hospitals. Continuous surveillance is needed for monitoring the of MDR strains.

 
Keyword(s): A. BAUMANNII, MDR, GENE DETERMINANTS, MLVA
 
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