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Paper Information

Journal:   HEPATITIS MONTHLY   OCTOBER 2014 , Volume 14 , Number 10; Page(s) 0 To 0.
 
Paper: 

APOLIPOPROTEIN C3 GENE POLYMORPHISMS ARE NOT A RISK FACTOR FOR DEVELOPING NON-ALCOHOLIC FATTY LIVER DISEASE: A META-ANALYSIS

 
 
Author(s):  ZHANG HAIYING, CHEN LIZHEN, XIN YONGNING*, LIU YANG, XUAN SHIYING*
 
*  DEPARTMENT OF GASTROENTEROLOGY, QINGDAO MUNICIPAL HOSPITAL, QINGDAO 266021, SHANDONG PROVINCE, CHINA
 
Abstract: 

Context: Our objective was to evaluate the effect of gene polymorphisms of apolipoprotein C3 (APOC3) on the development of non-alcoholic fatty liver disease (NAFLD) in different populations.
Evidence Acquisition: We performed a meta-analysis of all relevant studies published in the literature. A total of 115 clinical trials or reports were identified, but only seven trials met our inclusion criteria. A meta-analysis was performed according to the Cochrane Reviewers’ Handbook recommendations.
Results: Five hospital-based and two population-based case-control studies were included in the final analysis. The overall frequency of APOC3 gene polymorphisms was 67.5% (1177.1745) in NAFLD and 68.8% (988/1437) in controls. The summary odds ratio for the association of gene polymorphisms of APOC3 and the risk of NAFLD was 1.03 (95% CI: 0.89-1.22), which was not statistically significant (P>0.05).
Conclusions: Our meta-analysis, while not ruling out possible publication bias, showed no association between gene polymorphisms of APOC3 and the risk of NAFLD development in different populations in the world.

 
Keyword(s): APOLIPOPROTEIN, POLYMORPHISMS, NAFLD
 
References: 
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