Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   IRANIAN JOURNAL OF PUBLIC HEALTH   AUGUST 2014 , Volume 43 , Number SUPPLEMENT 2; Page(s) 31 To 31.
 
Paper: 

CHARACTERIZATION OF OVERT AND OCCULT HEPATITIS B VIRUS INFECTION AMONG HTLV-1 POSITIVE HEALTHY CARRIERS IN THE NORTHEAST OF IRAN; AN HTLV-I ENDEMIC AREA

 
 
Author(s):  CHENARI MARYAM, NOROUZI MEHDI, GHALICHI LEILA, REZAEE ABDOLRAHIM, RAFATPANAH HOOSHANG, YARI ATEFEH, JAZAYERI SEYED MOHAMMAD
 
* 
 
Abstract: 

Background: To date, no studies have provided data on hepatitis B virus (HBV) prevalence among asymptomatic, healthy human T-lymphotropic virus (HTLV-I) positive carriers. This sero- and molecular epidemiology study was performed on patients in the Northeast of Iran, which is an endemic area for HTLv-I infection.
Methods: 109 sera were collected from HTLV-I positive healthy carriers who were admitted to Ghaem Hospital, Mashhad City. All were tested for HBV serology and subsequently, real time PCR was carried out on the samples, regardless of the results of the serology. Standard PCR and direct sequencing were applied on positive samples.
Results: All cases were negative for HBsAg. Anti-HBc and anti-HBs were positive in 34 (31.1%), and 35 (32%) individuals, respectively. There were 19 (17.4%) cases that were positive only for anti-HBs, and they had already received HBV vaccine, 16 (15%) were positive for both anti-HBs and anti- HBc, indicating a past-resolved HBV infection, 18 (16.5%) were isolated as anti-HBc, and 56 (51.34%) were negative for all HBV serological markers. Only one subject (0.9%) had detectable HBV DNA (2 153 copy/mL), and assigned as being an occult HBV infection.
Conclusion: The low prevalence of HBsAg, despite the high percentage of anti-HBc positive cases, might be related to the suppression effect of HTLV-I on surface protein expression. The low prevalence of HBV infection among HTLV-I positive healthy carriers from an endemic region indicates that the epidemiology of HTLV-I and HBV coinfection is related to the endemicity of HBV in that region, rather than HTLV-I endemicity.

 
Keyword(s): HTLV-I, HBV, COINFECTION
 
References: 
  • ندارد
 
  Yearly Visit 46
 
Latest on Blog
Enter SID Blog