Paper Information

Journal:   HEPATITIS MONTHLY   JULY 2014 , Volume 14 , Number 7; Page(s) 0 To 0.
 
Paper: 

PLASMA INTERLEUKIN-10: A LIKELY PREDICTIVE MARKER FOR HEPATITIS B VIRUS-RELATED ACUTE-ON-CHRONIC LIVER FAILURE

 
 
Author(s):  WANG KE, WU ZHE-BIN, YE YI NONG, LIU JING, ZHANG GENG LIN, SU YU JIE, HE HONG LIANG, ZHENG YU BAO, GAO ZHI LIANG*
 
* DEPARTMENT OF INFECTIOUS DISEASES, THIRD AFFILIATED HOSPITAL OF SUN YAT-SEN UNIVERSITY, GUANGZHOU, CHINA
 
Abstract: 

Background: The pathogenesis of HBV-related acute-on-chronic liver failure (HBV-ACLF) is mainly based on a heightened immune-inflammatory reaction; however, the intimate underlying mechanism remains unclear.
Objectives: The aim of the study was to explore potential key immune molecular targets that could serve as early predictive markers for HBV-ACLF.
Patients and Methods: Twenty-seven patients with acute exacerbation of chronic hepatitis B (CHB) (defined by: alanine transaminase
³20 ULN, total bilirubin ³5 ULN, 40%< prothrombin time activity £ 60%) and without cirrhosis were divided into 18 cases which did not progress to HBV-ACLF (defined by: prothrombin time activity < 40% and development within four weeks of hepatic encephalopathy and/or ascites) and nine cases that developed HBV-ACLF. Nine healthy people defined the normal control group (NC). Interleukin-1b (IL-1b), IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, TNF-a and IFN-g protein levels were assayed by Cytometric Bead Array (CBA) in blood plasma. The ELISA method was applied to confirm IL-10 detection using the CBA method.
Results: IL-4, IL-12p70 and IFN-
g were undetectable; IL-1b, IL-6, IL-8, IL-10 and TNF-a levels were significantly higher than in NC. Moreover, cytokines reached the highest levels in acute exacerbation of CHB, with the exception of IL-2 and IL-8. When comparing the HBV-ACLF patients prior to and at the time of ACLF diagnosis, IL-10 was the only cytokine that exhibited a significant decrease (P=0.008). IL-10 concentrations were positively correlated to ALT levels (r=0.711, P<0.001).
Conclusions: The assessment of plasma IL-10 levels in chronic hepatitis B acute exacerbation may provide an early predictive marker for progression to HBV-ACLF.

 
Keyword(s): CHRONIC HEPATITIS B, SEVERE EXACERBATION, CHRONIC LIVER FAILURE, CYTOKINES, INTERLEUKIN-10
 
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