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Paper Information

Journal:   IRANIAN JOURNAL OF PUBLIC HEALTH   AUGUST 2014 , Volume 43 , Number SUPPLEMENT 2; Page(s) 31 To 31.
 
Paper: 

THE EVALUATION OF HEPATITIS G/C VIRUS IN AMONG HIV POSITIVE PATIENTS AND GBV-C/HGV AFFECT IN THE HIV DISEASE PROGRESSION

 
 
Author(s):  PIROUZI ALIYAR, FEIZABADI MOHAMMAD MEHDI, BAHMANI MIRZA KHALIL, AFKARI ROUHI*
 
* CELLULAR AND MOLECULAR GERASH RESEARCH CENTER, SHIRAZ UNIVERSITY OF MEDICAL SCIENCES, SHIRAZ, IRAN
 
Abstract: 

Background: Individuals infected with the human immunodeficiency virus (HIV) are often co-infected with other pathogens, especially hepatitis viruses. HCV and GBV-C/HGV are blood-borne viruses that are highly prevalent among HIV/AIDS patients. The aims of this study were the evaluation of Hepatitis G Virus in among HIV Positive patients and GBV-C/HGV affect in the HIV disease progression.
Methods: One hundred and fifty HIV-infected patients (92 men and 58 women) were included in this study. Patients were categorized into four different high-risk groups: intravenous drug users (n=48), hemophiliacs (n=45), homosexuals (n=32) and heterosexuals (n=25). In addition, these patients are separated with history of kidney (n=35), liver (n=60) diseases and history of transfusion (n=55). RNA was extracted from 100
ml of serum or plasma using the RNX plus kit. Detection of GBV-C/HGV-RNA and HCV-RNA were performed using reverse transcription and nested PCR.
Results: GBV-C/HGV-RNA and HCV-RNA were found in 26.66% and 30% patients, respectively. The prevalence of GBV-C/HGV in intravenous drug users, hemophiliacs, homosexual and heterosexuals, history of kidney disease and history of liver disease group was 31.25%, 28.88 %, 21.88%, 20%, 28.58% and 25% respectively.
Conclusion: The prevalence of GBV-C and HCV in HIV infected case varied in different groups. Our study shows a significant relationship between coinfection with GBV-C and HIV Virus, because after 4 years slows the progression of HIV disease and liver diseases in HIV-infected patients.

 
Keyword(s): HUMAN IMMUNODEFICIENCY VIRUS (HIV), GBVC/ HGV, HCV
 
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